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  • Tazarotene and...

Tazarotene and Imiquimod Offer Similar Efficacy in Treating Plane Warts, reports study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-05-06T08:00:00+05:30  |  Updated On 6 May 2024 2:42 PM IST
Tazarotene and Imiquimod Offer Similar Efficacy in Treating Plane Warts, reports study
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Researchers have found that tazarotene 0.1% gel and imiquimod 5% cream offer similar efficacy in treating plane warts, according to a three-arm randomized controlled trial. Both treatments demonstrated significant improvements compared to baseline and placebo, but tazarotene may offer additional advantages, such as a safer profile regarding dyspigmentation and cost savings. The study was published in the journal Clinical and Experimental Dermatology by Hagar N. and colleagues.

Plane warts, particularly when multiple and recurrent, can be challenging to treat and may negatively impact a patient's quality of life. For lesions located in cosmetically sensitive areas, topical treatments are often preferred to minimize potential sequelae. This study aimed to compare the efficacy and tolerability of tazarotene 0.1% gel and imiquimod 5% cream in treating plane warts.

In this parallel three-arm randomized controlled trial, 60 patients were assigned to one of three groups: imiquimod, tazarotene, or placebo. Patients applied the corresponding treatment once daily at night for up to 12 weeks. The primary outcomes measured were the percentage of respondents with complete clearance and the type and frequency of side effects in each group.

The key findings of the study were as follows:

• Complete clearance was achieved in 50% of patients, while 15% experienced partial response and 35% showed no response.

• Complete clearance was achieved in 40% of patients, with another 40% experiencing partial response and 20% showing no response.

• There was no significant difference in treatment efficacy between the imiquimod and tazarotene groups (P=0.190).

• Both active treatments provided significant improvement over baseline and the placebo group (P=0.001).

• However, tazarotene 0.1% gel may offer advantages such as a safer profile regarding dyspigmentation and a lower cost.

Both treatments were generally well-tolerated, with no significant safety concerns reported. Side effects, including local irritation and inflammation, were manageable and did not differ significantly between the groups.

Tazarotene 0.1% gel appears to offer equivalent efficacy to imiquimod 5% cream in treating plane warts. Moreover, it provides maintained efficacy without recurrence, a safer profile regarding dyspigmentation, and an advantageous cost benefit. These findings suggest that tazarotene could be a preferred option for treating plane warts, particularly in cosmetically significant areas.

Reference:

Nofal, H., Omran, F., ElKholy, B., Nofal, S., & Nofal, A. (2024). Tazarotene is as effective and tolerable as imiquimod in the treatment of verruca plana, a comparative randomized clinical trial. Clinical and Experimental Dermatology. https://doi.org/10.1093/ced/llae133

Clinical and Experimental DermatologyPlane wartsTazarotene 0.1% gelImiquimod 5% creamTopical treatmentRandomized controlled trialEfficacyDyspigmentation
Source : Clinical and Experimental Dermatology
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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