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Topical application of flutamide 1% gel safely reduces inflammatory lesions of acne vulgaris
![Topical application of flutamide 1% gel safely reduces inflammatory lesions of acne vulgaris Topical application of flutamide 1% gel safely reduces inflammatory lesions of acne vulgaris](https://medicaldialogues.in/h-upload/2023/09/23/750x450_220805-untitled-design-2023-09-23t215633607.webp)
Flutamide 1% gel, when applied topically, improves inflammatory lesions of acne vulgaris and is associated with minimal side effects, says Amany Nassar in a recent study published in the Journal of Cutaneous Medicine and Surgery.
In this randomized controlled study of 54 patients with a history of acne vulgaris, half of the participants were treated with topical flutamide 1% gel and the other half were treated with a vehicle for eight weeks. Papule and pustule count reduced significantly in those treated with Flutamide gel, while there was no significant reduction in comedone count.
Acne vulgaris is a dermatological condition. Androgens play an essential role in the complex pathophysiology of the condition. Flutamide is a first-generation nonsteroidal antiandrogen used for acne treatment. In this study, researchers evaluated topical flutamide's therapeutic efficacy and safety in treating acne vulgaris.
The study had two groups, Groups A and B, each had 27 patients having mild to moderate acne vulgaris having inflammatory (papules and pustules) and non-inflammatory (comedones) lesions. Group A received twice daily application of Flutamide topical gel on the face for eight weeks. Group (B) was the control group.
There was a significant reduction in papules count and a highly significant decrease in pustules number from baseline. The adverse effects were minor, with scaling being the most frequently observed adverse effect.
They said, "We recommend that topical application of Flutamide 1% gel be tried on a larger number of patients with acne vulgaris, for longer duration and follow up following treatment."
The study explains the effectiveness of topical Flutamide 1% gel as a viable, efficient, and safe solution for acne vulgaris patients.
Reference:
Nassar A, Sayed AE, Samy A, Essam R. Efficacy and Safety of Topical Flutamide 1% Gel as an Adjunctive Therapy in the Treatment of Patients With Acne Vulgaris. Journal of Cutaneous Medicine and Surgery. 2023;0(0). doi:10.1177/12034754231191475
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751