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Topical remetinostat gel effective for treatment of basal cell carcinoma, Study finds
The mainstay of treatment for basal cell carcinoma (BCC) is surgical excision, which can result in significant associated morbidity, particularly for patients with recurrent tumors.
However, recently, researchers from the Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California have found out that remetinostat is a well-tolerated and effective topical treatment for reducing basal cell carcinoma disease burden in a clinically significant manner. Remetinostatis a histone deacetylase (HDAC) inhibitor.
The study is published in the Clinical Cancer Research Journal.
James M. Kilgour and colleagues previously conducted a drug repositioning screen using molecular data from human basal cell carcinoma and identified histone deacetylase (HDAC) inhibitors as a potential treatment for basal cell carcinoma and now are able to conduct the first proof-of-principle study of a topical pan-HDAC inhibitor, remetinostat, in human basal cell carcinoma.
The team of researchers conducted a phase II, open-label, single-arm, single-institution trial of a topical HDAC inhibitor. Participants with at least one basal cell carcinoma were recruited.
All participants applied 1% remetinostat gel three times daily for 6 weeks, with measurements of tumor diameter conducted at baseline and week 8.
Surgical excision of the remaining tumor was conducted at the end of the study and microscopic evaluation was performed. Thirty-three per-protocol tumors from 25 participants were included in the analysis.
The results of the study showed that the overall response rate, defined as the proportion of tumors achieving more than 30% decrease in the longest diameter from baseline to week 8, was 69.7% [90% confidence interval (CI), 54%–82.5%].
On pathologic examination, 54.8% of tumors demonstrated complete resolution. Pharmacodynamic analysis demonstrated similar levels of acetylated histone H3 in skin tissue before and after treatment, however, phosphorylation was increased. No systemic adverse events were reported.
As a result, it was concluded that remetinostat is a well-tolerated and effective topical treatment for reducing basal cell carcinoma disease burden in a clinically significant manner. This provides in-human validation of histone deacetylase inhibitors as a therapy for basal cell carcinoma.
DOI: 10.1158/1078-0432.CCR-21-0560
BDS, MDS( Pedodontics and Preventive Dentistry)
Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751