Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Dermatology
  • Dermatology News
  • Trifarotene- The...

Trifarotene- The latest retinoid for acne management

Written By : Dr Manoj Kumar Nayak |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-09-06T09:00:43+05:30  |  Updated On 6 Sept 2021 9:01 AM IST
Trifarotene- The latest retinoid for acne management
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Trifarotene- The latest retinoid for acne management

Retinoids, both topical and systemic are a crucial class of drugs for dermatologists. They are classified into four generations of topical and systemic agents. The latest addition to this list is trifarotene, a topical retinoid details of which where published recently in the Indian Journal of Dermatology, Venereology and Leprology.

Retinoids act through retinoid receptors comprising mainly of 2 families- RAR (retinoic acid receptors α, β and γ) and RXR (retinoid X receptors α, β and γ). It is believed that the major effects and side effects of retinoids are mediated through the RARs. The dermal RAR-β might be significantly responsible for retinoid-induced skin irritation. The DNA sequence called retinoic acid response element attaches itself with the RAR–RXR heterodimer. On binding of a ligand, the RAR–RXR heterodimer acts as a transcription factor, resulting in the expression of a number of proteins involved in growth and regulation.

Trifarotene is a fourth-generation topical retinoid with potent and selective RAR-γ agonist activity, claimed to have an improved efficacy/safety ratio when compared with less or non-selective RAR agonists especially causing reduced retinoid induced skin irritation. It has no activity at RXRs, and significantly less activity at RAR-β and RAR-α (16- and 65-fold lower than activity at RAR-γ, respectively). Trifarotene may modulate retinoid-mediated pathways involved in cell adhesion, skin hydration and proteolysis, through the following mechanisms in addition to classic pathways-

  1. Cell adhesion: Trifarotene downregulates dystonin weakening hemidesmosomes, thereby interfering with cell adhesion. This induces migration of keratinocytes which facilitates comedolysis.
  2. Transport/skin hydration: Trifarotene improves skin hydration by induction of aquaporin-3 channels and peptidyl arginine deiminase 1 in skin and thus promotes barrier function of the skin. Trifarotene may also maintain the cutaneous pH homeostasis by impacting the ammonium/ammonia (NH4+/NH3) balance.
  3. Proteolysis- Trifarotene downregulates membrane metallo-endopeptidase involved in elastin degradation thereby improving the skin texture and decreasing wrinkling.

Trifarotene produced the same comedolytic effect as other known retinoids such as tazarotene and all-trans-retinoic acid, at about ten times lower dose in mouse models. Trifarotene penetrates the skin with an exponential distribution from the stratum corneum to the rest of the epidermis and dermis including the pilosebaceous unit. It is greater than 99.9% bound to plasma proteins.

Trifarotene received Food and Drug Administration (FDA) approval for the topical treatment of acne vulgaris in patients nine years of age and older, thus becoming the first retinoid approved in the past 20 years for management of acne. The US FDA granted orphan drug status to trifarotene for the treatment of lamellar ichthyosis in 2014.

The efficacy and safety were determined by two large scale phase III trials- PERFECT 1 and PERFECT 2. double-blind, randomized, vehicle-controlled, 12-week studies

Trifarotene is available as 50 mg/g (0.005%) cream. The use of a moisturizer before and after the application of trifarotene is recommended as frequently as needed.

Safety on long-term use up to 52 weeks for moderate facial and truncal acne has been demonstrated in patients between ages 9 and 54. Oral animal studies have shown that trifarotene can cross the placental barrier and is also excreted in the breast milk of lactating rats. Hence, trifarotene must be strictly avoided in pregnancy, breastfeeding and in women planning pregnancy. Age <9 years and >65 years, active eczema and hypersensitivity to trifarotene are additional contraindications for using this drug.

In conclusion trifarotene is the latest fourth generation selective RAR-γ agonist topical retinoid approved for acne, increasing the spectrum for treatment of acne with lesser local side effects. More studies on large groups, and comparative trials with other retinoids are needed to establish where trifarotene lies in terms of efficacy, tolerability and long-term safety in comparison to other retinoids.

Source- Santhosh P, Kidangazhiathmana A. Trifarotene – The latest retinoid. Indian J Dermatol Venereol Leprol 2021;87:742-5.


Retinoidsacne vulgarisIJDVLtrifaroteneFood and drug administration
Source : Indian Journal of Dermatology, Venereology and Leprology
Dr Manoj Kumar Nayak
Dr Manoj Kumar Nayak

    MBBS

    Dr Manoj Kumar Nayak has completed his M.B.B.S. from the prestigious institute Bangalore medical college and research institute, Bengaluru. He completed his M.D. Dermatology from AIIMS Rishikesh. He is actively involved in the field of dermatology with special interests in vitiligo, immunobullous disorders, psoriasis and procedural dermatology. His continued interest in academics and recent developments serves as an inspiration to work with medical dialogues.He can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story

    Editorial

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer - Dr Aditya Murali

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer...

    Aspirin in Primary Prevention- When to Consider?

    Aspirin in Primary Prevention- When to Consider?

    Featured image representing medico legal

    What's the Role of Expert Opinion in Medical Negligence?

    7- Point Discharge Protocol for AECOPD: Time to Inculcate in Practice

    7- Point Discharge Protocol for AECOPD: Time to Inculcate in Practice

    Aspirin Use in Women Aged 40-50 with Diabetes and Hypertension: Identifying the Ideal Candidates

    Aspirin Use in Women Aged 40-50 with Diabetes and Hypertension: Identifying the Ideal Candidates

    View All

    Journal Club Today

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer - Dr Aditya Murali

    Real-World Case study: Darbepoetin Alfa for Chemotherapy-Induced Anemia in Metastatic Breast Cancer...

    View All

    Health News Today

    Health Bulletin 09/ May/ 2025

    Health Bulletin 09/ May/ 2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok