Adrenalectomy may improve Diabetes symptoms in nearly half of primary aldosteronism patients with DM

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-01-26T20:00:26+05:30 | Updated On 26 Jan 2023 8:00 PM IST

China: Researchers from China found that Adrenalectomy was successful in remitting and improving Diabetes in nearly half of primary aldosteronism (PA) patients with Diabetes. Longer duration of hypertension, a higher concentration of urinary magnesium and higher 24 h urinary potassium could hinder the remission and improvement, but examination of urinary electrolytes can predict the outcomes of Diabetes in PA patients. The study results were published in the journal BMC Endocrine Disorders.

Primary aldosteronism (PA) is characterized by hypertension, excessive aldosterone excretion, and low serum potassium. Adrenalectomy and mineralocorticoid receptor antagonists are the recommended therapies for PA patients. Recent literature showed that adrenalectomy would improve insulin secretion in PA patients despite some studies stating that blood glucose levels did not alter. Hence Chinese researchers from the West China Hospital, Sichuan University conducted a study to evaluate the outcome of diabetes after adrenalectomy and determine the factors associated with that in PA patients.

Also Read: Delaying antibiotics for neutropenic fever may not affect survival of cancer inpatients

PA patients with DM (PA + DM patients) who received adrenalectomy were recruited into the study. Based on the diabetes outcomes after treatment, patients were classified into 3 groups, including “remission”, “improved” and “unchanged” groups. The preoperative factors affecting the outcome of DM after adrenalectomy were uncovered by univariate and multivariate logistic regression analysis.

Key findings of the study:

A total of 54 PA + DM patients received adrenalectomy.
Post adrenalectomy, 16.7%, 33.3%, and 50.0% of patients were classified into the “remission”, “improved” and “unchanged” groups, respectively.
The factors negatively associated with remission or improvement from DM after adrenalectomy were longer duration of hypertension (P = 0.029), a higher concentration of urinary magnesium (P = 0.031), and higher 24 h urinary potassium (P = 0.049).

Also Read: Bedside lung ultrasound useful option for accurate diagnosis of pneumonia in kids

Thus, diabetes could be improved with adrenalectomy in nearly half of the patients with Diabetes.

Further reading: Liu, Y., Lin, L., Yuan, C. et al. Recovery from diabetes mellitus in primary aldosteronism patients after adrenalectomy. BMC Endocr Disord 22, 331 (2022). https://doi.org/10.1186/s12902-022-01254-6

BMC Endocrine disordersDiabetesYu Liu

Source : BMC Endocrine Disorders

Dr.Niharika Harsha B

BDS, MDS

Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751