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  • Dapagliflozin tied to...

Dapagliflozin tied to significant reduction in ventricular repolarization parameters in CVD patients with glycemic control

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-07-13T10:45:11+05:30  |  Updated On 13 July 2023 11:23 AM IST
Dapagliflozin tied to significant reduction in ventricular repolarization parameters in CVD patients with glycemic control
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New research revealed that Dapagliflozin exerts antihyperglycemic effects irrespective of the cardiovascular disease status and also reduces the risk of ventricular arrhythmia in Cardiovascular Disease patients. The study was published in the Journal of Diabetes and its Complications.

The prevalence of diabetes has increased enormously in recent years. Diabetes has been recognized as a global pandemic, leading to the development of high-risk cardiovascular diseases (CVD). In people with diabetes mellitus (DM), dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2i), is prescribed as it has antihyperglycemic effects as well as a strong correlation with a reduced risk of cardiovascular events. Recent literature has also suggested the antiarrhythmic effects of Dapagliflozin. But there is limited data on the effects of dapagliflozin on the effects of glycemic control provided by anti-diabetic drugs on electrocardiographic (ECG) parameters. Hence researchers conducted a study to understand the effects of Dapagliflozin on ventricular repolarization heterogeneity parameters in patients with type 2 DM.

Nearly 140 patients with a known diagnosis of type 2 DM who were newly prescribed dapagliflozin in addition to standard anti-diabetic therapy were enrolled in the study. Based on their cardiovascular disease status, the patients were divided into two groups. The effect of dapagliflozin treatment on ventricular repolarization parameters (frontal plane QRST angle, Tp-e interval, Tp-e/QTc, QTc, and QTc dispersion) was investigated, and patient groups were compared before and after treatment.

Key findings:

  • Among 140 patients, 70 (50 %) had CVD, and 70 (50 %) did not have CVD.
  • There were significant reductions in ventricular repolarization parameters over the study period in the CVD group with diabetes with Dapagliflozin treatment.
  • Mean fQRST angle, Tp-e interval, Tp-e/QTc, QTc, and QTc dispersion were significantly lower than baseline values at 6-month follow-up visits in the CVD group.

Thus, the study found that dapagliflozin has positive cardioprotective effects in diabetic patients. It had made many positive alterations in the ventricular arrhythmia risk parameters in patients with CVD thus reducing the risk of ventricular arrhythmia.

Further reading: The effect of dapagliflozin therapy on ventricular repolarization parameters in electrocardiography in patients with diabetic cardiovascular disease. https://doi.org/10.1016/j.jdiacomp.2023.108547

Journal of Diabetes and its ComplicationSefa Erdi ÖmürDiabetesCardiologyCardiovascular diseases
Source : Journal of Diabetes and its Complications.
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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