Diabetics with low HDL-C levels prone to peritoneal dialysis-related peritonitis

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-05-27T19:30:20+05:30 | Updated On 27 May 2022 7:30 PM IST

China: Patients with diabetes and concurrent low HDL-C levels are at a higher risk for peritoneal dialysis-related peritonitis (PDRP) in peritoneal dialysis (PD) patients, shows a recent study in the journal Diabetology & Metabolic Syndrome.

In patients undergoing peritoneal dialysis, low levels of high-density lipoprotein cholesterol (HDL-C) and diabetes are common. Considering this, Yajuan Huang, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, and colleagues aimed to examine the association between the coexistence of diabetes and a low level of HDL-C and the first episode of PDRP in patients with PD.

For this purpose, the researchers retrospectively investigated patients with PD from January 1, 2003, to May 31, 2020, in four PD centers. PD patients were categorized into four groups: no comorbidities, low HDL-C only, diabetes only, and diabetes plus low HDL-C. They collected and compared the clinical and laboratory baseline data of the four groups. Multivariate Cox regression analysis was used to analyze the association between diabetes coexisting with low HDL-C levels and the first episode of PDRP.

The study included a total of 1013 patients with PD. The mean age was 49.94 ± 14.32 years, and 597 (58.99%) patients were males.

The study led to the following findings:

A total of 301 (29.7%) patients had their first episodes of PDRP, and low HDL-C levels coexisted with diabetes in 72 patients with PD.
After adjusting for confounding factors, a low level of HDL-C coexisting with diabetes was significantly associated with the first episode of PDRP in our study (hazard ratio: 2.81).
The associations among HDL-C, diabetes, and PDRP were consistent in the following subgroups: sex, age, and pre-existing CVD.

"The results showed that compared to no comorbidities, the presence of both diabetes and t low HDL-C levels were more associated with the first episode of PDRP in patients with PD than either diabetes or low HDL levels alone," wrote the authors. "Therefore, in order to avoid PDRP, it is important to maintain normal levels of HDL-C in patients with diabetes with PD."

Reference:

Zhang, R., Zhang, X., Tang, X. et al. The association between diabetes coexisting with low levels of high-density lipoprotein cholesterol and peritoneal dialysis-related peritonitis. Diabetol Metab Syndr 14, 60 (2022). https://doi.org/10.1186/s13098-022-00832-x

Diabetology & Metabolic Syndromeperitoneal dialysishigh density lipoprotein cholesteroldiabetesperitonitis

Source : Diabetology & Metabolic Syndrome

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751