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  • Elevated TyG-BMI may...

Elevated TyG-BMI may Predict Mortality in Critically ill Ischemic Stroke Patients: Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-04-26T11:15:17+05:30  |  Updated On 26 April 2025 3:08 PM IST
Elevated TyG-BMI may Predict Mortality in Critically ill Ischemic Stroke Patients: Study
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A new study published in the journal of BMC Cardiovascular Diabetology showed that in patients with critically sick ischemic stroke (IS), increased triglyceride glucose-body mass index (TyG-BMI) is substantially linked to an increased risk of short-term all-cause mortality.

Focal neurological dysfunction and cerebral tissue necrosis are hallmarks of ischemic stroke, which is usually caused by insitu thrombotic events or the embolization of atherothrombos from proximal artery sources. Moreover, the most frequent causes of ischemic stroke attributable to other causes include hematological illnesses, such as essential thrombocythemia, polycythemia vera, and thrombotic thrombocytopenic purpura, which can also present as acute ischemic stroke.

Calculated by multiplying fasting triglyceride and fasting glucose levels, the triglyceride-glucose index is a simple and accurate surrogate diagnostic for evaluating insulin resistance (IR), which is associated with IS. In order to fill up current research gaps and provide more accurate biomarker references for therapeutic applications, this study, which is based on the eICU database, examines the connection between the TyG-BMI and 28-day mortality in critically ill IS patients.

The effects of the TyG-BMI on 28-day hospital and intensive care unit mortality were examined using multivariate Cox regression models. To investigate the nonlinear association between the TyG-BMI and 28-day mortality, restricted cubic splines (RCS) were used. K-M curves were used to compare the results of the various TyG-BMI groups. Furthermore, subgroup and interaction analyses were conducted to confirm the results' resilience.

The mean age of the 1,362 severely sick IS patients that were included was 68.41 ± 14.16 years, and 47.50% of them were male. The high TyG-BMI group had substantially greater ICU and 28-day hospital mortality, according to multivariate Cox regression analysis. The TyG-BMI and 28-day inpatient mortality had a nonlinear positive connection, according to RCS analysis.

There was a 37.3% rise in 28-day hospital mortality for every 1 standard deviation (SD) increase in TyG-BMI below the inflection point of TyG-BMI = 380.37, and an 87.9% decrease in 28-day hospital mortality for every 1 SD increase in TyG-BMI beyond 380.376. The P value for the log-likelihood ratio test is 0.004. The TyG-BMI showed a strong positive linear connection in RCS for 28-day ICU mortality. Overall, among critically sick IS patients in the US, an elevated TyG-BMI is substantially associated with a higher risk of short-term all-cause mortality.

Reference:

Ouyang, Q., Xu, L., & Yu, M. (2025). Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke. Cardiovascular Diabetology, 24(1). https://doi.org/10.1186/s12933-025-02583-1

BMC Cardiovascular Diabetologytriglyceride glucose-body mass indexIschemic stroke
Source : BMC Cardiovascular Diabetology
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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