Evidence of genetic correlation suggests causal relationship between hypothyroidism and rheumatoid arthritis

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-02-18T16:00:21+05:30 | Updated On 19 Feb 2024 2:58 PM IST

A recent study explored the intricate relationship between hypothyroidism and rheumatoid arthritis (RA). This research filled a crucial gap in understanding the shared genetic architecture between these debilitating conditions amidst the ongoing controversy surrounding their connection. The key findings of the study were published in the recent edition of Frontiers in Immunology journal.

This study was conducted by Zhifang Peng and team which involved a variety of advanced methodologies to dissect the genetic underpinnings of hypothyroidism and rheumatoid arthritis. This research utilized data from public genome-wide association studies and employed cutting-edge techniques like the linkage disequilibrium score regression, Mendelian randomization and transcriptome-wide association study.

The results from the analysis revealed a significant positive genetic association between hypothyroidism and RA within localized genomic regions. Also, the Mendelian randomization analysis pointed at a potential causal relationship that indicates at hypothyroidism which may contribute to the development of rheumatoid arthritis.

The research looked deeper by integrating gene expression data and identifying various tissues, including the spleen, lung and small intestine, where the genetic associations between the two conditions were strong. This comprehensive approach led to the identification of the major shared risk genes, including TYK2, IL2RA, and IRF5 that offers valuable insights into the biological mechanisms underlying both hypothyroidism and RA.

The investigation unveils a previously unrecognized genetic relationship between hypothyroidism and rheumatoid arthritis. This discovery enhanced our understanding of these complex diseases but also lays the groundwork for more targeted and effective interventions. The findings of this study holds promise for the future of precision medicine, giving way for tailored treatments that could address the shared genetic vulnerabilities of hypothyroidism and rheumatoid arthritis.

Reference:

Peng, Z., Huang, W., Tang, M., Chen, B., Yang, R., Liu, Q., Liu, C., & Long, P. (2024). Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis. In Frontiers in Immunology (Vol. 14). Frontiers Media SA. https://doi.org/10.3389/fimmu.2023.1286491

Frontiers in Immunologyrheumatoid arthritishypothyroidism

Source : Frontiers in Immunology

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751