High serum leptin linked to Aortic stiffness in diabetes patients

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-07-14T09:00:33+05:30 | Updated On 14 July 2023 12:17 PM IST

In patients with type 2 diabetes, serum leptin is positively correlated with aortic stiffness, says an article published in Frontiers in Bioscience-Landmark.The number of individuals living with diabetes mellitus (DM) increases on a global scale. Regardless of differences in race or ethnicity, obesity, smoking, hypercholesterolemia, and hypertension are independently linked with the risk of cardiovascular disease (CVD) in diabetes individuals. In order to detect cardiovascular risk at an early stage, Tsung-Jui and colleagues looked at the link between blood leptin levels and aortic stiffness in patients with type 2 diabetes.

After being screened at a hospital in Eastern Taiwan for eligibility, 128 diabetic patients in total were enrolled. Applanation tonometry was used to measure aortic stiffness, which was indicated by a carotid-femoral pulse wave velocity (cfPWV) greater than 10 m/s. Leptin and other related indicators were measured in fasting serum levels using enzyme immunoassay or biochemical analysis.

The key findings of this study were:

1. In the group of patients with aortic stiffness, 46 diabetics with cfPWVs greater than 10 m/s were included.

2. Aortic stiffness group (n = 82) was substantially older (p = 0.019) than the control group (n = 82), and it had higher body fat mass (p = 0.002), systolic blood pressure (SBP), serum triglycerides (p = 0.02), and serum leptin (p 0.001).

3. Aortic stiffness was also linked to insulin resistance and worse blood sugar regulation (p = 0.026).

4. Age, SBP ( = 0.176; p = 0.033), the logarithmically transformed urinary albumin-creatinine ratio, and serum leptin levels were all independently associated with cfPWV values in the multivariable linear regression analyses examining the correlations between aortic stiffness and clinical variables.

5. Only leptin, according to the analysis, was linked to a greater likelihood of aortic stiffness.

Reference:

Wu, T.-J., Wu, D.-A., & Hsu, B.-G. (2023). Serum Leptin Level is Positively Correlated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus. In Frontiers in Bioscience-Landmark (Vol. 28, Issue 6, p. 128). IMR Press. https://doi.org/10.31083/j.fbl2806128

Frontiers in Bioscience-Landmarkserum leptinaortic stiffness

Source : Frontiers in Bioscience

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751