Hyperglycemia and comorbidities related to dementia risk: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-01-28T09:00:58+05:30 | Updated On 28 Jan 2022 9:01 AM IST

South Korea: A recent study published in the journal Diabetes Care has suggested an association of mild degrees of hyperglycemia and presence of comorbidities with incident dementia. This indicates that dementia can be prevented by intervention during the prodromal stage of chronic disease (e.g., prediabetes).

Kyungdo Han, Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea, and colleagues carried out the study to examine the risk of incident dementia according to fasting glucose levels and presence of comorbidities.

For this purpose, the researchers selected 8,400,950 subjects aged ≥40 years who underwent health examinations in 2009–2010 using a health insurance claims database and the results of biennial health examinations in South Korea. They were followed until 2016. The participants' baseline characteristics were categorized by the presence of diabetes (yes/no) and glycemic status as normoglycemia, impaired fasting glucose (IFG), new-onset diabetes, or known diabetes (duration <5 years or ≥5 years). Adjusted hazard ratios (aHRs) was estimated for dementia occurrence in each category.

Based on the study, the researchers found the following:

During the observation period of 48,323,729 person-years, all-cause dementia developed in 353,392 subjects (4.2%).
Compared with normoglycemia, aHRs were 1.01 in IFG, 1.45 in new-onset diabetes, 1.32 in known diabetes <5 years, and 1.62 in known diabetes ≥5 years.
Associations between ischemic heart disease and chronic kidney disease with incident dementia were affected by the presence of diabetes.
Ischemic stroke showed a greater association with incident dementia than diabetes.

The researchers concluded, "mild degrees of hyperglycemia and presence of comorbidities were associated with incident dementia." "Intervention during the prodromal stage of chronic disease (e.g., prediabetes) could be considered for the prevention of dementia.

Reference:

Woo Jung Kim, Seo Jung Lee, Eun Lee, Eun Young Lee, Kyungdo Han; Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study. Diabetes Care 2022; dc210957. https://doi.org/10.2337/dc21-0957

dementiahyperglycemiaDiabetes Care

Source : Diabetes Care

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751