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Hyperglycemia predicts adverse prognosis in advanced pancreatic cancer patients

China: Recent research from China reported that the overall survival in patients with advanced pancreatic cancer is worsened by hyperglycemia. The study results were published in the journal Endocrine. Diabetes mellitus is a global pandemic with increased mortality and morbidity. It is a prevalent comorbidity in pancreatic cancer. Studies in the past measured the association...
China: Recent research from China reported that the overall survival in patients with advanced pancreatic cancer is worsened by hyperglycemia. The study results were published in the journal Endocrine.
Diabetes mellitus is a global pandemic with increased mortality and morbidity. It is a prevalent comorbidity in pancreatic cancer. Studies in the past measured the association between diabetes and pancreatic cancer outcomes. But there is limited research on the impact of hyperglycemia on the prognosis of patients with advanced pancreatic cancer. Hence Xinzhe Zhu et al conducted a study to understand the associations between hyperglycemia and clinical variables or prognosis of patients with advanced pancreatic cancer.
Using a prospectively maintained database, information was collected on patients with advanced pancreatic cancer. the patients were divided into the hyperglycemia group (fasting blood glucose ≥7.0 mmol/L) and the normoglycemia group (fasting blood glucose < 7.0 mmol/L). Patients with preexisting diabetes were not included in these groups. The associations between hyperglycemia and clinical variables or prognosis were analyzed.
Key findings of the study:
- Nearly 25.3% were diagnosed with hyperglycemia, among 697 patients with advanced pancreatic cancer and no prior history of diabetes.
- A higher risk of developing hyperglycemia was observed in patients older than 65 years (P = 0.044).
- Worse prognosis was seen in patients with hyperglycemia than those with normoglycemia (median survival, 7.5 vs. 8.8 months, P < 0.001).
- An increased mortality was associated with Hyperglycemia in patients with advanced pancreatic cancer (hazard ratio = 1.38; P = 0.003).
Thus, hyperglycemia predicted the overall survival in patients with advanced pancreatic disease.
Further reading: Zhu, X., Xu, H., Xiao, Z. et al. Hyperglycemia predicts adverse prognosis in advanced pancreatic cancer patients. Endocrine (2023). https://doi.org/10.1007/s12020-022-03196-4
BDS, MDS
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.