Intermittent fasting may help achieve disease remission in patients with type 2 diabetes

USA: Study of a 3-month intermittent fasting diet intervention among 36 people with diabetes showed that patients achieved diabetes remission, defined as an HbA1c level of less than 6.5% at least one year following discontinuation of diabetes medication. The study findings were published in the Journal of Clinical Endocrinology & Metabolism.

The authors found almost 90% of participants, including those who took blood sugar-lowering agents and insulin, reduced their diabetes medication intake after intermittent fasting. Fifty-five percent of these people experienced diabetes remission, discontinued their diabetes medication and maintained it for at least one year.

Intermittent fasting diets have become popular in recent years as an effective weight loss method. With intermittent fasting, you only eat during a specific window of time. Fasting for a certain number of hours each day or eating just one meal a couple of days a week can help your body burn fat. Research shows intermittent fasting can lower your risk of diabetes and heart disease.

"Type 2 diabetes is not necessarily a permanent, lifelong disease. Diabetes remission is possible if patients lose weight by changing their diet and exercise habits," said Dongbo Liu, Ph.D., of Hunan Agricultural University in Changsha, China. "Our research shows intermittent fasting, Chinese Medical Nutrition Therapy (CMNT), can lead to diabetes remission in people with type 2 diabetes. These findings could have a major impact on the over 537 million adults worldwide who suffer from the disease."

The study challenges the conventional view that diabetes remission can only be achieved in those with a shorter diabetes duration (0-6 years). Sixty-five percent of the study participants who achieved diabetes remission had a diabetes duration of more than 6 years (6-11 years).

"Diabetes medications are costly and a barrier for many patients who are trying to effectively manage their diabetes. Our study saw medication costs decrease by 77% in people with diabetes after intermittent fasting," Liu said.

"Better methods to monitor and promote compliance to a daily eating pattern in humans is necessary to accurately assess the benefits of time-restricted eating (TRE).

Reference:

Emily N C Manoogian, Lisa S Chow, Pam R Taub, Blandine Laferrère, Satchidananda Panda. Time-restricted Eating for the Prevention and Management of Metabolic Diseases. Endocrine Reviews, 2022; 43 (2): 405 DOI: 10.1210/endrev/bnab027