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New onset diabetes may predict development of low-risk pancreatic mucinous cysts: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2 Aug 2021 3:30 AM  |  Updated On 2 Aug 2021 3:30 AM
New onset diabetes may predict development of low-risk pancreatic  mucinous cysts: Study
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New onset diabetes may accurately estimate the development of low-risk mucinous cysts, suggests a study published in the Pancreatology Journal.

Pancreatic cancer is one of the most common cancer worldwide; also, it is associated with a high mortality rate. The five-year survival rate in all patients is just 5% and has not altered significantly over the past five decades. The relationship between diabetes mellitus and pancreatic cancer has been known for over 125 years, some studies have proved that the chances of patients with low-risk lesions developing pancreatic cancer are higher as compared to healthy individuals. Hence, it is essential for regular continued surveillance in patients with low-risk lesions.

A study was conducted by a group of researchers from Columbia University Irving Medical Center, NY, USA to investigate the association between new-onset diabetes and progression in patients with low-risk mucinous cysts.

The researchers assessed a prospectively maintained cohort of a total of 442 patients with a suspected mucinous cyst without worrisome features (WF) or high-risk stigmata (HRS).

Additionally, Multivariable Cox models were developed for development to worrisome features and high-risk stigmata, with diabetes status, formulated as both time independent and dependent covariates.

The adjusted cumulative risk of progression was calculated using the corrected group prognosis method.

The findings of the study are as follows:

Ø The 5-year total progression rates to worrisome features and high-risk stigmata were 12.8 and 3.6%, respectively.

Ø The new-onset diabetes was strongly linked with progression to high-risk stigmata (HR = 11.6; 95%CI, 3.5–57.7%).

Ø The new-onset diabetes was not linked with worrisome features.

Ø Among patients with cysts less than 10 mm at baseline, those who developed new onset diabetes had a 5-year adjusted total risk of progression to high-risk stigmata of 8.6% as compared to only 0.8% for patients without new-onset diabetes.

Ø Among patients with cysts between 20–29 mm, those who developed new-onset diabetes during surveillance had a 5-year adjusted cumulative risk of progression of 53.5% compared to only 7.5% for patients without new-onset diabetes.

The researchers concluded that new-onset diabetes may accurately estimate the development of low-risk mucinous cysts. Pending validation with large-scale studies, these findings bolster routine diabetes examination among patients screened for suspected Intraductal Papillary Mucinous Neoplasm or Mucinous Cystic Neoplasms

Reference

A study titled, "New onset diabetes predicts progression of low risk pancreatic mucinous cysts" by Schweber A published in the Pancreatology Journal.

https://doi.org/10.1016/j.pan.2020.09.015


pancreascystcancerdiabetesbiomarkerlow-risk lesionsnew onset diabetesPancreatic cancer riskmortalityprogression
Source : Pancreatology Journal
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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