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  • SGLT-2 inhibitors tied...

SGLT-2 inhibitors tied to lower risk of End-Stage Renal Disease, Finds Study

Written By : Dr. Nandita Mohan |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-11-12T18:32:56+05:30  |  Updated On 12 Nov 2020 6:32 PM IST
SGLT-2 inhibitors tied to lower risk of End-Stage Renal Disease, Finds Study
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Researchers have noted that the initiation of SGLT-2i vs oGLD was associated with a lower risk of End-Stage Renal Disease (ESRD) and all-cause death, according to a recent study published in the Journal of Diabetes, Obesity, and Metabolism.

Many randomized trials have demonstrated a lower risk of cardiovascular (CV) events with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes (T2D) at high CV risk. Also, prior real-world data suggested similar SGLT-2i effects in T2D patients with a broader risk profile, but these studies focused on heart failure and death.

However, real-world evidence from routine clinical practice elucidating the effects of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on renal outcomes and mortality in patients with type 2 diabetes (T2D) is limited. Hence, Eun Sil Koh and colleagues from the Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary's Hospital, Seoul, Republic of Korea conducted the present study on Korean patients with T2D.

Using data from the Korean National Health Insurance Service database, the authors studied a total of 701,674 patients who were identified with T2D. "We divided these patients into new-users of SGLT-2i and new-users of other glucose-lowering drugs (oGLD). Using propensity scores, patients in the two groups were matched 1:1. We examined the risk of end-stage renal disease (ESRD) and all-cause death", Koh describes.

Out of the total sample size, 45,016 patients were included in each group, and baseline characteristics were well-balanced between all groups.

The key findings observed were-

  1. Use of SGLT-2i versus oGLD was associated with a lower risk of ESRD and all-cause death
  2. In a subgroup analysis by eGFR, initiation of SGLT2i vs oGLD was associated with a lower risk of progression to ESRD among patients with eGFR 60-90 and <60 ml/min/1.73m
    2
    and lower risk of all-cause death associated with SGLT-2i versus oGLD in patients with eGFR ≥90 and 60-90 ml/min/1.73m2.

Therefore, the authors concluded that "in this large nationwide study of Korean patients with T2D, initiation of SGLT-2i vs oGLD was associated with a lower risk of ESRD and all-cause death."


SGLT-2 inhibitorsEnd stage renal Diseasetype 2 diabetes mellitussodium-glucose cotransporter 2 inhibitorJournal of Diabetes obesity and metabolism
Source : Journal of Diabetes, Obesity and Metabolism
Dr. Nandita Mohan
Dr. Nandita Mohan

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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