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  • SGLT2 Inhibitors tied...

SGLT2 Inhibitors tied to lower CV risk relative to DPP-4 Inhibitors in Diabetes: BMJ

Dr. Kamal Kant KohliBy Dr. Kamal Kant KohliPublished On 2020-09-24T09:56:32+05:30  |  Updated On 24 Sep 2020 4:26 AM GMT
SGLT2 Inhibitors tied to lower CV risk relative to DPP-4 Inhibitors in Diabetes: BMJ

Previous trials have shown that SGLT2 inhibitors can reduce the risk of heart conditions such as heart attack, stroke, and heart failure compared with placebo.But some of these trials had important limitations, making it difficult to interpret the results, and data on the effects of individual SGLT2 inhibitors on the heart are limited.Researchers have found in a new retrospective Study...

Previous trials have shown that SGLT2 inhibitors can reduce the risk of heart conditions such as heart attack, stroke, and heart failure compared with placebo.

But some of these trials had important limitations, making it difficult to interpret the results, and data on the effects of individual SGLT2 inhibitors on the heart are limited.

Researchers have found in a new retrospective Study that short-term use of sodium glucose cotransporter 2 (SGLT2) inhibitors is associated with reduced risk for major cardiovascular events in patients with type 2 diabetes, compared with dipeptidyl peptidase-4 (DPP-4) inhibitors.The study has been published in The BMJ.

The researchers conducted the study to compare the risk of cardiovascular events between sodium glucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors among people with type 2 diabetes in a real world context of clinical practice.

They used Canadian and U.K. databases and matched over 200,000 new users of SGLT2 inhibitors with new users of DPP-4 inhibitors.

They found that compared with DPP-4 inhibitors, SGLT2 inhibitors were associated with a reduced risk of heart attack, stroke or cardiovascular death combined (11.4 events per 1000 person years versus 16.5 events per 1000 person years).

SGLT2 inhibitors were also associated with decreased risks of individual events. For example, heart attack (5.1 v 6.4 events per 1000 person years), cardiovascular death (3.9 v 7.7 events per 1000 person years), heart failure (3.1 v 7.7 events per 1000 person years), and all cause mortality (8.7 v 17.3 events per 1000 person years).

However, SGLT2 inhibitors had more modest benefits for stroke (2.6 v 3.5 events per 1000 person years).

Results were similar in subgroups defined by patient age, sex, past insulin use, and history of cardiovascular disease.

The risk reduction was strongest for cardiovascular death. The SGLT2 inhibitors canagliflozin, dapagliflozin, and empagliflozin all showed similar cardiovascular risk reductions.

The authors concluded that short term use of SGLT2 inhibitors was associated with a decreased risk of cardiovascular events compared with the use of DPP-4 inhibitors.

"These findings suggest that SGLT2 inhibitors offer cardioprotective benefits among people with type 2 diabetes in a real world setting, although additional studies are needed to determine if these benefits persist long term."they said.

The BMJ article (Free)

SGLT2 inhibitors cardioprotective action DPP4 inhibitors Diabetes BMJ cardiovascular risk sodium glucose cotransporter 2 sodium-glucose cotransporter 2 inhibitor 
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues section. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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