Vitamin D deficiency tied to greater risk of MACE and heart failure in diabetics

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-10-02T20:00:42+05:30 | Updated On 2 Oct 2023 8:01 PM IST

Vitamin D deficiency is associated with the development of various conditions like diabetes, hypertension, cardiovascular disease, cancers, multiple sclerosis and rheumatoid arthritis. Vitamin D deficiency is prevalent worldwide and more pronounced during Winter and Spring.

A recent study published in the Journal of Diabetes and its Complications has found Vitamin D deficiency to be a risk marker for major adverse cardiovascular events and heart failure in type 1 and type 2 diabetes but not for microvascular complications or all-cause mortality.

According to data from the UK Biobank, 20 % of individuals with type 2 diabetes had vitamin D deficiency. In both T1D and T2D, vitamin D deficiency has been associated with a higher risk of all-cause mortality; however, its role in developing complications is arguable. In the cohort study of 1448 T1D adults and 770 T2D adults, researchers investigated vitamin D deficiency as a risk marker for complications in such individuals.

Individuals in the lowest vitamin D decile were classified as deficient. Outcomes-based on medical records and registers included mortality, MACE, heart failure, a composite kidney endpoint, albuminuria progression and sight-threatening eye disease. Cox proportional hazard models were used.

The key results of the study are:

There was an association between Vitamin D deficiency and a higher risk of MACE (aHR 2.6) in T1D, but not T2D.
The risk of heart failure was higher in those with vitamin D deficiency in T1D and T2D individuals.
There was no association between Vitamin D deficiency and the development of microvascular complications or mortality.

They said we had a unique opportunity to evaluate the association between vitamin D deficiency and the complications.

Vitamin D deficiency was a risk marker for MACE and heart failure in individuals with type 1 diabetes.

Study Limitations are small sample size and a lack of data on medication changes and vitamin supplementation.

Reference:

Tougaard, N. H., Hansen, T. W., & Persson, F. (2023). Vitamin D deficiency and development of complications in individuals with type 1 and type 2 diabetes: A cohort study. Journal of Diabetes and Its Complications, 37(10), 108611. https://doi.org/10.1016/j.jdiacomp.2023.108611

vitamin d deficiencyMACEheart failuretype 1 diabetestype 2 diabetesT2DMT1DMJournal of Diabetes and Its Complicationsmajor adverse cardiovascular events

Source : Journal of Diabetes and its Complications

Aditi

BDS, MDS in Periodontics and Implantology

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751