Gluten-free diet in patients with type 1 diabetes and celiac disease improved outcomes, study says

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-03T12:30:59+05:30 | Updated On 3 Sept 2022 3:00 PM IST

Italy: A systematic review, published in Diabetes Research and Clinical Practice, highlights that young people with type 1 diabetes (T1D) and celiac disease (CD) who adhere to a gluten-free diet (GFD) have better outcomes in regular growth and stable BMI without having any negative effects on HbA1c levels or insulin requirements.Gluten-free

There have been conflicting results from studies evaluating the effect of a gluten-free diet on clinical, biochemical, and psychosocial outcomes in young people with type 1 diabetes and celiac disease. Enza Mozzillo and colleagues undertook this study in order to assess the effects of a gluten-free diet on development, metabolic management, and quality of life in children and adolescents with type 1 diabetes and celiac disease.

A thorough search was done for this study, encompassing papers released within the previous 15 years. The PICOS framework was applied to the selection process, and the GRADE system was employed to evaluate the evidence.

The key findings of this study were;

1. Studies comparing young people with T1D + CD on GFD to those with T1D alone found no appreciable changes in growth metrics, HbA1c, the number of hypoglycemic episodes, or total daily insulin doses.

2. Studies evaluating the impact of the implementation of the GFD revealed steady BMI and HbA1c.

3. Only two studies evaluated QoL, and they found no differences between young people with T1D and CD and those with T1D alone, as well as between CD diagnoses before and after the introduction of GFD.

In conclusion, according to this study's comprehensive evaluation, following the GFD is linked to normal growth without a negative rise in BMI. Additionally, GFD is linked to greater post-prandial glucose but has no deleterious effects on HbA1c or insulin dosages. Even though it is only supported by data from a small amount of research, following the GFD is linked to better lipid profiles and a higher quality of life.

Reference:

Mozzillo, E., Franceschi, R., Di Candia, F., Rosanio, F. M., Leonardi, L., Fedi, L., Rosà, V., Cauvin, V., Franzese, A., & Loredana Marcovecchio, M. (2022). The impact of gluten-free diet on growth, metabolic control and quality of life in youth with type 1 diabetes and celiac disease: A systematic review. In Diabetes Research and Clinical Practice (Vol. 191, p. 110032). Elsevier BV. https://doi.org/10.1016/j.diabres.2022.110032

gluten free diettype 1 diabetesceliac diseaseDiabetes Research and Clinical Practice

Source : Diabetes Research and Clinical Practice

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751