- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
High coffee consumption may significantly increase prostate cancer risk among smokers, suggests study
High coffee consumption may significantly increase prostate cancer risk among smokers, suggests study published in the Current Developments in Nutrition.
A study was done to evaluate the association between coffee consumption and prostate cancer risk. They evaluated 27,111 male Finnish smokers, ages 50-69 years, from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort with self-reported coffee consumption data. Multivariable proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for prostate cancer risk based on 2,584 men with a prostate cancer diagnosed during 30 years of follow-up.
Results: Thirty percent of the men reported consuming at least three cups of coffee daily (overall median, 2.3 cups/day). Compared with men consuming the least coffee daily ( >0-1 cups/day; 11.5%), those who drank >4 cups/day (12.8%) had a statistically significant increase in prostate cancer risk (HR: 1.23, 95% CI: 1.04-1.46; overall p-trend < 0.001), whereas non-coffee drinkers (2.5%) had the lowest risk (HR: 0.81, 95% CI: 0.59-1.12). HRs for the intermediate coffee consumption categories were 1.00 (95% CI: 0.87-1.16) for >1-2 cups/day (26.6%); 1.05 (95% CI: 0.91-1.21) for >2-3 cups/day (29.9%), and 1.13 (95% CI: 0.97-1.32) for >3-4 cups/day (16.7%). Elevated risk among the heaviest coffee drinkers was similar for men diagnosed with non-aggressive disease (stage < =2 and Gleason score < 8) or aggressive disease (stage >=3 or Gleason score >=8): HR=1.22 (95% CI: 0.96-1.54), p-trend=0.02 and HR=1.37 (95% CI: 1.00-1.88), p-trend=0.01, respectively. Prostate cancer risk was also similar across subgroups based on age at randomization, BMI, cigarettes smoked/day, years of smoking, alcohol consumption, and trial supplementation group, but the elevated risk did appear greater for taller men: comparing highest coffee consumption (>4 cups/day) to lowest ( >0-1 cups/day), HR=1.47 (95% CI: 1.15-1.88), p-trend= 0.002 versus HR=1.06 (95% CI: 0.84-1.33), p-trend= 0.06 for men with height below the median value of 174.0 cm.In this population of male smokers, consuming more than 4 cups of coffee daily was associated with significantly increased prostate cancer risk.
Reference:
Weinstein, Stephanie & Nelson, Shakira & Parisi, Dominick & Männistö, Satu & Loftfield, Erikka & Albanes, Demetrius. (2024). Coffee Consumption and Prostate Cancer Risk in the Alpha-Tocopherol, Beta Carotene Cancer Prevention Study. Current Developments in Nutrition. 8. 102577. 10.1016/j.cdnut.2024.102577
Keywords:
High, coffee, consumption, significantly, increase, prostate cancer risk, among smokers, study, Current Developments in Nutrition, Weinstein, Stephanie & Nelson, Shakira & Parisi, Dominick & Männistö, Satu & Loftfield, Erikka & Albanes, Demetrius
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.