High consumption of sugary drinks ups risk of cardiometabolic disease: Study
USA: People who consume high amount of sugar-sweetened beverages (sodas and fruit drinks) may be at higher cardiometabolic risk, says a recent study published in The Journal of Nutrition.
The study stated that higher consumption of sugar-sweetened beverages (SSB) was associated with emerging features of dyslipidemia that have been tied to higher cardiometabolic risk.
Prospective cohort studies have reported a relation between the consumption of sugar-sweetened beverage and dyslipidemia. There is not much evidence linking the consumption of SSB to emerging dyslipidemia features, which can be characterized by variation in lipoprotein particle size, remnant-like particle (RLP), and apolipoprotein concentrations.
Against the above background, Danielle E Haslam, Brigham and Women's Hospital, Boston, Massachusetts, USA, and colleagues aimed to investigate the association between SSB consumption and plasma lipoprotein cholesterol, apolipoprotein, and lipoprotein particle size concentrations among US adults.
For this purpose, the researchers examined participants from the Framingham Offspring Study (FOS) (1987-1995; n = 3047) and the Women's Health Study (1992; n = 26,218). They quantified plasma LDL-C, apolipoprotein (apo) B, HDL-C, apoA1, triglyceride (TG), non-HDL-C, total: HDL-cholesterol ratio, and apoB: apoA1 concentrations in both the cohorts. apoE, apoC3, RLP-TG, and RLP-cholesterol concentrations were quantified in FOS only.
Calculation of lipoprotein sizes was done from NMR signals for lipoprotein particle subclass concentrations (triglyceride-rich lipoprotein particles [TRL-P; very large, large, medium, small, and very small], HDL-particles [HDL-P; large, medium, and small]), and LDL-particles [LDL-P; large, medium, and small]. Food frequency questionnaire data estimated SSB consumption.
The study led to the following findings:
- SSB consumption was positively associated with LDL-C, apoB, TG, RLP-TG, RLP-C, non-HDL-C concentrations and total: HDL cholesterol and apoB: apoA1 ratio, and negatively associated with HDL-C and apoA1 concentrations.
- After adjustment for traditional lipoprotein risk factors, SSB consumers had smaller LDL-P and HDL-P sizes, lower concentrations of large LDL-P and medium HDL-P, and higher concentrations of small LDL-P, small HDL-P, and large TRL-P.
The researchers conclude, "higher SSB consumption was associated with multiple emerging features of dyslipidemia that have been linked to higher cardiometabolic risk in US adults."
Reference:
Danielle E Haslam, Daniel I Chasman, Gina M Peloso, Mark A Herman, Josée Dupuis, Alice H Lichtenstein, Caren E Smith, Paul M Ridker, Paul F Jacques, Samia Mora, Nicola M McKeown, Sugar-sweetened Beverage Consumption and Plasma Lipoprotein Cholesterol, Apolipoprotein, and Lipoprotein Particle Size Concentrations in U.S. Adults, The Journal of Nutrition, 2022;, nxac166, https://doi.org/10.1093/jn/nxac166
