High plasma caffeine levels reduce risk of osteoarthritis and obesity: BMC

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-03-08T02:00:40+05:30 | Updated On 8 March 2024 2:01 AM IST

A recent study published in the latest issue of BMC Medicine explored the complex relationship between caffeine consumption and its effects on human health. The outcomes of this study unveiled the multifaceted impacts of caffeine on the body in relation to obesity and joint health.

The research utilized innovative methods to dissect the clinical effects of caffeine by leveraging genetic variants closely associated with caffeine metabolism. The research team led by Loukas Zagkos included phenome-wide association studies (PheWAS) and Mendelian randomization to unravel the intricate interplay between circulating caffeine levels and various health outcomes.

The findings revealed a compelling link between genetically predicted circulating caffeine levels and reduced risks of obesity, osteoarthrosis and osteoarthritis among caffeine consumers. The higher plasma caffeine levels were associated with a lower risk of these conditions that suggests a potential protective effect of caffeine on body weight and joint health.

Further, the study unearthed intriguing insights into the underlying biological mechanisms that drive these beneficial effects. Proteomic and metabolomic analyses unveiled lower levels of chronic inflammation, improved lipid profiles and alterations in protein and glycogen metabolism among the individuals with increased circulating caffeine levels.

The study emphasized the significance of these findings that provide novel evidence supporting the notion that long-term increases in circulating caffeine may confer health benefits, particularly in reducing obesity and joint-related conditions. Overall, the results offer promising implications for public health and clinical practice but also warrants further investigation to fully comprehend the translational relevance of these findings.

Reference:

Zagkos, L., Cronjé, H. T., Woolf, B., de La Harpe, R., Burgess, S., Mantzoros, C. S., Elliott, P., Yuan, S., Larsson, S. C., Tzoulaki, I., & Gill, D. (2024). Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization. In BMC Medicine (Vol. 22, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1186/s12916-024-03298-y

BMC Medicinecaffeine consumptionosteoarthritisobesity

Source : BMC Medicine

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751