Ketone supplement a novel therapeutic for boosting brain function in obesity
New research published in The Journal of Physiology has shown that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.People with obesity are known to be at a higher risk of developing cognitive impairment and neurodegenerative diseases.This new study found that giving a ketone supplement three times a day for 14 days...
New research published in The Journal of Physiology has shown that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.
People with obesity are known to be at a higher risk of developing cognitive impairment and neurodegenerative diseases.
This new study found that giving a ketone supplement three times a day for 14 days enhanced blood flow to the brain and improved aspects of cognitive function, like working memory and processing speed, in adults with obesity.
Supplements specifically containing the ketone body beta-hydroxybutyrate (B-OHB) that are safe for human consumption are relatively new and have mostly been investigated for physical performance (in sports and military settings).
It has previously been shown that ketone supplements are beneficial for older adults with mild cognitive impairment (MCI) and dementia.
In this study, the researchers have extended these findings by demonstrating that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity, who are at risk of developing neurocognitive impairment.
Adults with obesity volunteered to consume either a ketone supplement or a taste-matched placebo supplement three times per day, 15 minutes before each meal (breakfast, lunch, and dinner).
The study was what is called a randomised placebo-controlled crossover study- in other words, the participants were randomly assigned to take the supplement or the placebo for the first 14-day period, and they were then switched to the other condition for another 14-day period. This allows researchers to compare responses to the supplement versus a placebo in the same participants.
The researchers provided participants all meals and snacks for both 14-day intervention periods.
They measured cognitive function using validated tests via an application on an iPad, and measured brain blood flow using what's called a duplex ultrasound of the extra-cranial (neck) arteries.
They also took blood samples to measure hormones that are like fertiliser for the brain, helping neurons grow and improving cognitive functions.
Dr Jeremy Walsh, first author on the study said,"Once validated with a larger group of people, we expect that these supplements can be used to protect and improve brain health in people with obesity."
The study was conducted at the University of British Columbia's Okanagan Campus and was funded by a Grant-in-Aid from the Heart and Stroke Foundation of Canada. Authors received support from the Michael Smith Foundation for Health Research during the conduct of the research.
Dr Kartikeya Kohli is an Internal Medicine Consultant at Sitaram Bhartia Hospital in Delhi with super speciality training in Nephrology. He has worked with various eminent hospitals like Indraprastha Apollo Hospital, Sir Gangaram Hospital. He holds an MBBS from Kasturba Medical College Manipal, DNB Internal Medicine, Post Graduate Diploma in Clinical Research and Business Development, Fellow DNB Nephrology, MRCP and ECFMG Certification. He has been closely associated with India Medical Association South Delhi Branch and Delhi Medical Association and has been organising continuing medical education programs on their behalf from time to time. Further he has been contributing medical articles for their newsletters as well. He is also associated with electronic media and TV for conduction and presentation of health programs. He has been associated with Medical Dialogues for last 3 years and contributing articles on regular basis.