Vitamin D supplementation beneficial in managing dyslipidemia

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-15T02:00:28+05:30 | Updated On 15 Nov 2023 12:04 PM IST

Vitamin D supplementation benefits lipid profile and is beneficial as a dietary intervention for managing dyslipidemia, says Nima Radkhah and colleagues in their recent study “The effect of vitamin D supplementation on lipid profile: an umbrella review of meta-analysis” published in Advances in Nutrition.

In this study, vitamin D significantly decreased TG levels (no significant effect on LDL-C levels). THEY NOTED THAT vitamin D effects on HDL-C and TC levels produced contradictory findings. The team also reported doses ≥ 4000 IU/day and duration of intervention ≤12 weeks as critical variables.

Vitamin D is beneficial in preventing and controlling risk factors associated with non-communicable chronic diseases, but the findings remain conflicting. In the present study, researchers investigated the effect of vitamin D supplementation on low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) as components of lipid profile using data from PubMed, Scopus, Web of Science, and Cochrane Database of Systematic Reviews. The umbrella meta-analysis followed the PRISMA guidelines.

The key findings of this study are:

The team included 25 meta-analyses.
Vitamin D significantly decreased TG and TC levels.
Vitamin D supplementation increased HDL-C levels.
In the Weighted Mean Difference (WMD) analysis, Vitamin D significantly reduced only TG levels.

Concluding further, they said that vitamin D supplementation is a beneficial adjuvant therapy for those with vitamin D deficiency in managing lipid profile levels.

Vitamin D might decrease TG levels. It also reduces TC levels in those supplemented with a dose of >4000 IU/day or for less than 14 weeks.

They said results should be interpreted with caution due to high heterogeneity and the poor quality of the included meta-analyses.

The findings of this study support that vitamin D supplementation is a beneficial adjuvant therapy in managing lipid profile levels among those with vitamin D deficiency.

BDS, MDS in Periodontics and Implantology

Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751