- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Chemotherapy drug linked to high risk of hearing loss in young children with cancer
The chemotherapy drug cisplatin is an effective cancer treatment for many children with cancer, but unfortunately it can cause permanent hearing loss. Results from a new study show that the hearing of very young children is impacted early during treatment and is affected to a greater extent than that of older children. The findings are published by Wiley early online in CANCER, a peer-reviewed journal of the American Cancer Society.
Previous studies have shown that up to 60% of children treated with cisplatin suffer from hearing loss. To evaluate the course of cisplatin-related hearing loss, Dr. Bruce Carleton, PharmD, an investigator and director of the Pharmaceutical Outcomes Program at BC Children's Hospital in Vancouver, British Columbia, and his colleagues examined data from 368 Canadian childhood cancer patients who received cisplatin and underwent a total of 2,052 audiological assessments. All patients were off cisplatin within three years of initiating the medication.
Three years after starting therapy, 75% of patients ≤5 years old and 48% of patients >5 years old had experienced cisplatin-related hearing loss. At three months and one year after initiating therapy, 27% and 61% of patients ≤5 years old had experienced cisplatin-related hearing loss, respectively. A higher total dose of cisplatin at three months, co-prescriptions of the chemotherapy drug vincristine, and a longer duration of concomitantly administered antibiotics exacerbated cisplatin-related hearing loss over time.
The authors noted that the underlying mechanism explaining the higher occurrence of cisplatin-related hearing loss in young children remains unclear, but maturing structures within the ear might be more vulnerable to the toxic effects of cisplatin.
"Audiological monitoring at each cycle of cisplatin treatment will allow research to advance more quickly to find the mechanistic basis of why younger children are more vulnerable to hearing loss and how best to protect hearing while being given this life-saving therapy," said Dr. Carleton, who is also a professor at the University of British Columbia's Faculty of Medicine and director of the Provincial Health Services Authority's Therapeutic Evaluation Unit.
Penelope Brock, MD, PD, MA, of Great Ormond Street Hospital in London, authored an editorial that accompanies the study. She said that the work "comes from an excellent international collaboration between audiologists and oncologists and brings new insight into this extremely serious life-impacting direct effect of cisplatin on children."
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33848
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:Â editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751