- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Ciprofloxacin plus fluocinolone acetonide, combo effective for treating Acute Otitis External
USA: Ciprofloxacin 0.3%, plus fluocinolone acetonide 0.025%, the otic solution is efficient and safe in treating acute otitis external (AOE), states an article published in the JAMA Network Open.
Otitis externa, an inflammatory condition (acute or chronic) of the external auditory canal is common worldwide with a prevalence of 10%. Patients with Acute Otitis External (AOE) present with otalgia, tenderness, diffuse ear canal oedema, and otorrhea. If untreated, the infection can spread to nearby tissue and bone. Topical antibiotics (mainly ciprofloxacin) are the preferred first-line treatment because they efficiently reach the infection site, present low adverse events and minimize the development of antibiotic resistance. In AOE, the addition of corticosteroids to ototopical antibiotic treatment is believed to enhance the resolution of the inflammatory response and improve associated symptoms. Fluocinolone acetonide is a corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties.
Chu L, Benchmark Research, Austin, Texas and colleagues conducted a study to evaluate the superiority of ciprofloxacin, 0.3%, plus fluocinolone acetonide, 0.025%, otic solution vs ciprofloxacin and fluocinolone acetonide alone to treat AOE.
Researchers enrolled 493 patients aged 6 months or older with AOE of less than 21 days duration for the study. Patients were randomly assigned to receive ciprofloxacin plus fluocinolone(n-197), ciprofloxacin(n-196), or fluocinolone(n-100 ) twice daily for 7 days and were evaluated on day 1 (visit 1; baseline), days 3 to 4 (visit 2; conducted via telephone), days 8 to 10 (visit 3; end of treatment), and days 15 to 17 (visit 4; test of cure). The primary outcome was a therapeutic cure (clinical and microbiological) at the end of the treatment period. The principal secondary endpoint was the time to end ear pain.
Key findings of the study,
• Therapeutic cure in the population with ciprofloxacin plus fluocinolone was statistically comparable to that of ciprofloxacin(P = 0.30) and fluocinolone(P =0 .06) at visit 3 and significantly superior to ciprofloxacin at visit 4 (P =0 .04).
• A statistically faster resolution of otalgia was achieved among patients treated with ciprofloxacin plus fluocinolone vs ciprofloxacin ( P =0 .002) or fluocinolone (P <0 .001).
• Ciprofloxacin plus fluocinolone demonstrated statistical superiority in sustained microbiological response vs ciprofloxacin (P =0 .04) and fluocinolone (P =0 .01) and the microbiological outcome vs fluocinolone by visit 3 (P =0 .01) and ciprofloxacin by visit 4 (P =0 .02).
• Fifteen mild or moderate. adverse events related to study medications were registered.
The authors conclude that otic solution containing ciprofloxacin, 0.3%, plus fluocinolone acetonide, 0.025%, was efficacious and safe in treating AOE but in the main study endpoint of therapeutic cure, it did not demonstrate superiority to the use of ciprofloxacin and fluocinolone acetonide alone.
The findings suggest that to manage patients with AOE, concerning both the bacterial infection and the typical disease signs and symptoms, a combination of the antibiotic (ciprofloxacin) and the corticosteroid (fluocinolone acetonide) is beneficial, the authors wrote.
Chu L, Acosta AM, Aazami H, et al. Efficacy and Safety of Ciprofloxacin Plus Fluocinolone Acetonide Among Patients With Acute Otitis Externa: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(7):e2221699. doi:10.1001/jamanetworkopen.2022.21699
BDS
Dr. Hiral patel (BDS) has completed BDS from Gujarat University, Baroda. She has worked in private dental steup for 8years and is currently a consulting general dentist in mumbai. She has recently completed her advanced PG diploma in clinical research and pharmacovigilance. She is passionate about writing and loves to read, analyses and write informative medical content for readers. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751