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Intratonsillar Immunotherapy found efficacious in Allergic Rhinitis

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-11T09:00:42+05:30  |  Updated On 11 Nov 2023 1:33 PM IST
Intratonsillar Immunotherapy found efficacious in Allergic Rhinitis
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Intratonsillar Immunotherapy found efficacious in Allergic Rhinitis in the latest trial suggests a new study published in the Annals of Allergy, Asthma & Immunology

A lower adherence rate existed in patients received allergen specific immunotherapy (AIT) due to its lengthy period and side effects even though it is the only curative treatment for IgE-mediated allergies. Therefore, exploring innovative AIT routes are necessary.

This study was designed to explore the efficacy and safety of the intratonsillar injection of house dust mite (HDM) extract in patients with HDM-induced allergic rhinitis.

A randomized double-blind placebo-controlled clinical trial was conducted. Eighty patients with HDM-induced AR were randomized to receive 6 intratonsillar injections with HDM extract or placebo over 3 months. The total nasal symptom score (TNSS), Visual Analogue Scale (VAS) of nasal symptoms, combined symptom and medication score (CSMS), Mini Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ), and serum allergen-specific IgG4 to D. pteronyssinus were all monitored at baseline, 3, 6, and 12 months after the treatment finished. The intent-to-treat (ITT) and per protocol set (PPS) are both analyzed.

Results:

The primary endpoints TNSS and ΔTNSS were improved significantly at 3 months after AR patients finished a 3-month 6-injection intratonsillar immunotherapy (ITIT) by comparing to the placebo treatment in both ITT and PPS. VAS, CSMS and MiniRQLQ were also improved significantly at 3 months after treatment in PPS. However, the improvement effect of ITIT at 6 and 12 months was limited and uncertain based on the data. The increase of serum Der p IgG4 in the active group was significantly higher than that in the placebo group at 3, 6, and 12 months after the treatment finished. Adverse events were monitored, and no systemic adverse reactions were observed.

The clinical trial showed that intratonsillar injection with HDM extract was safe and effective in patients with AR. Optimizing the protocol and allergen formulations is expected to increase and maintain the efficacy of this novel approach.

Reference:

Zhang J, Yang X, Chen G, Hu J, He Y, Ma J, Ma Z, Chen H, Huang Y, Wu Q, Liu Y, Yu L, Zhang H, Lai H, Zhang J, Zhai J, Huang M, Zou Z, Tao A. Efficacy and Safety of Intratonsillar Immunotherapy for Allergic Rhinitis: A Randomized, Double-blind, Placebo-Controlled Clinical Trial. Ann Allergy Asthma Immunol. 2023 Oct 30:S1081-1206(23)01392-3. doi: 10.1016/j.anai.2023.10.029. Epub ahead of print. PMID: 37913839.

Keywords:

Intratonsillar, Immunotherapy, found, efficacious, Allergic Rhinitis, latest trial, Zhang J, Yang X, Chen G, Hu J, He Y, Ma J, Ma Z, Chen H, Huang Y, Wu Q, Liu Y, Yu L, Zhang H, Lai H, Zhang J, Zhai J, Huang M, Zou Z, Tao, Annals of Allergy, Asthma & Immunology, allergic rhinitis; house dust mite; intratonsillar immunotherapy; randomized controlled trial; specific immunotherapy.

IntratonsillarImmunotherapyfoundefficaciousAllergic Rhinitislatest trialAnnals of AllergyAsthma & Immunol
Source : Annals of Allergy, Asthma & Immunology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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