Viral Infection in olfactory system tied with accelerated onset of Alzheimer's disease: Study

USA: Viral infraction and associated inflammation and dysregulation of myelination of the olfactory system may disrupt downstream hippocampal function, possibly accelerating the onset of Alzheimer's disease, a recent study in Neurobiology of Aging has shown.

The findings could lead to new therapies that can detect Alzheimer's disease (AD) earlier while helping to illuminate the role that viruses and the olfactory system play in driving the illness.

According to the study, viruses can inflame and disrupt connections between the olfactory system, which governs the sense of smell, and the part of the brain associated with memory and learning, possibly accelerating the onset of Alzheimer's disease.

"We know that one of the early signs of Alzheimer's disease is losing the sense of smell," said the study's lead author Andrew Bubak, PhD, assistant research professor in the division of neurology at the University of Colorado School of Medicine.

Bubak's team focused on the olfactory tract, olfactory bulb and the hippocampus, the area of the brain which manages memory and learning.

They examined messenger RNA in the brain tissue of six individuals from Colombia who had Familial Alzheimer's disease (FAD) and tissue from a control group without AD. They found signatures of viral infection in the olfactory bulbs of the FAD group and inflammation in the olfactory tract which carries information to the hippocampus. They also discovered altered myelination in the olfactory tract. Myelin is a protective fatty layer around nerves that allows electrical impulses to move quickly and smoothly. If it's damaged, signalling stalls.

"These findings raise the possibility that viral infection and associated inflammation and dysregulation of myelination of the olfactory system may disrupt hippocampal function, contributing to the acceleration of FAD progression," the study said.

The study's senior author, Diego Restrepo, PhD, professor of cell and developmental biology at the CU School of the Medicine, said viruses have long been suspected of playing a role in cognition problems. Some studies have associated the SARS-CoV-2 virus, which causes COVID-19, with dementia. The virus, which travels through the nose, causes some of those infected to lose their sense of smell.

At the same time, the varicella zoster virus which causes shingles and the herpes simplex virus can deposit amyloid beta, a protein critical to the development of AD, in the olfactory bulb. The viruses often linger for years even after symptoms have disappeared.

"Our hypothesis is that some viruses accelerate Alzheimer's disease," Restrepo said. "Does the loss of smell specifically accelerate Alzheimer's? That's the question."

Bubak and Restrepo suspect inflammation and the amyloid deposits in the olfactory system interrupt communication with the hippocampus. Without sensory input, they believe, the hippocampus begins to degenerate.

"The whole olfactory pathway goes to the hippocampus. If you decrease the signaling along that pathway then you get less signaling to the hippocampus," Bubak said. "If you don't use it, you lose it."

The researchers hope to next focus on better understanding the relationship between the olfactory system and the hippocampus in the context of viral susceptibility and neurodegeneration.

Reference:

Andrew N. Bubak, Laetitia Merle, Christy S. Niemeyer, B. Dnate' Baxter, Arianna Gentile Polese, Vijay Ramakrishnan, Johana Gomez, Lucia Madrigal, Andres Villegas-Lanau, Francisco Lopera, Wendy Macklin, View ORCID ProfileSeth Frietze, Maria A. Nagel, View ORCID ProfileDiego Restrep doi: https://doi.org/10.1101/2022.07.19.500641