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  • Vitamin D deficiency ...

Vitamin D deficiency linked to severity of chronic rhinosinusitis with nasal polyposi, claims research

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-12-09T07:45:53+05:30  |  Updated On 9 Dec 2024 10:37 AM IST
chronic rhinosinusitis
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A new study published in the Ear, Nose and Throat Journal found that the severity of chronic rhinosinusitis with nasal polyposis is influenced by serum vitamin D levels. A persistent infection of the sinonasal mucosa lasting 12 weeks or more, chronic rhinosinusitis with nasal polyposis (CRSwNP) is characterized by certain symptoms and clinical indicators. This illness significantly impairs quality of life and interferes with everyday tasks.

The involvement of Vitamin D in the development of allergy disorders, such as CRSwNP, has garnered a lot of interest lately. As it influences both the innate and adaptive immune systems by altering the T-helper 1 (Th1)/Th17 response to a Th2/Treg less inflammatory profile, vitamin D has been demonstrated to have immunomodulatory effects and is crucial for the regulation of multiple immune cells, including T cells and dendritic cells, as well as for lowering inflammation through a variety of mechanisms. Thus, this study was to look into the connection between the severity of CRSwNP and serum vitamin D levels.

Serum vitamin D levels were assessed in 104 individuals with uncontrolled CRSwNP who were scheduled for functional endoscopic sinus surgery after failing all forms of medication treatment. The Lund-Mackay (LM) score, total nasal polyp scores, Sinonasal Outcome Test-22 (SNOT-22), and absolute eosinophil counts were used to compare vitamin D levels across individuals.

The average age of the 104 patients that were included was 42.09 ± 13.3 years, and 63.5% of them were men. Vitamin D levels were 57.9 ± 31.2 nmol/L on average. The mean score on the SNOT-22 was 65.49 ± 21.3. The LM score was 14.48 ± 6.64 on average. The overall score for nasal polyps was 4.3 ± 2.08. Vitamin D levels did not correlate with other factors, however, they did have a negative correlation with polyp grade (r = -.264, P =.007) and LM score (r = -.210, P =.032).

Overall, patients with CRSwNP frequently have vitamin D insufficiency or inadequacy. More evidence that low vitamin D levels are linked to more severe CRSwNP was established when the study discovered a negative correlation between low blood vitamin D levels. These early results suggest that vitamin D measurement may be useful in the clinical assessment and treatment of CRSwNP.

Source:

Magboul, N. A., Alotaibi, M., Aldokhayel, F., Almazyad, L. M., Alkwai, K., Almutawa, N., Alotaibi, M., Alyousef, M. Y., Alsaleh, S., & Alroqi, A. (2024). Association Between Serum Vitamin D Level and Uncontrolled Chronic Rhinosinusitis With Nasal Polyposis. In Ear, Nose & Throat Journal. SAGE Publications. https://doi.org/10.1177/01455613241302892

Ear Nose & Throat Journalchronic rhinosinusitisnasal polyposisserum vitamin D
Source : Ear, Nose & Throat Journal
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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