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Bariatric Surgery Reduces Cancer Risk in Adults with NAFLD and Obesity: Study

Dr. Nandita MohanWritten by Dr. Nandita Mohan Published On 2021-04-01T19:38:46+05:30  |  Updated On 2021-04-02T06:55:35+05:30
Bariatric Surgery Reduces Cancer Risk in Adults with NAFLD and Obesity: Study

According to recent research, it has been observed by the investigators at the Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey that bariatric surgery was associated with significant reductions in the risks of any cancer and obesity-related cancer in Nonalcoholic Fatty Liver Disease (NAFLD) patients with...

According to recent research, it has been observed by the investigators at the Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey that bariatric surgery was associated with significant reductions in the risks of any cancer and obesity-related cancer in Nonalcoholic Fatty Liver Disease (NAFLD) patients with severe obesity.

The study is published in the Journal of Gastroenterology.

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and increased risk of cancer. The impacts of bariatric surgery on cancer risk in NAFLD patients are unknown.

Therefore, Vinod K. Rustgi and colleagues conducted the present study to investigate the effect of bariatric surgery on cancer risk in patients with NAFLD and severe obesity using the Marketscan database.

The authors conducted a retrospective cohort study of 18 to 64 years old newly diagnosed NAFLD patients with severe obesity. Cox proportional hazard models were used to examine the association between bariatric surgery, modeled as a time-varying covariate, and the risks of any cancer and obesity-related cancer, while accounting for confounding using inverse probability of treatment weighting (IPTW).

A total of the 98,090 patients were included in the study, 33,435 (34.1%) received bariatric surgery. In those without surgery,1,898 incident cases of cancer occurred over 115,890.11 person-years of follow-up, compared with 925 cancer cases over 67,389.82 person-years among surgery patients (crude rate ratio 0.84; 95% CI: 0.77 to 0.91)

The results showed that-

a. The IPTW-adjusted risk of any cancer and obesity-related cancer was reduced by 18% (hazard ratio [HR] 0.82; 95% CI, 0.76-0.89) and 25% (HR 0.65; 95% CI 0.56-0.75), respectively, in patients with versus without bariatric surgery.

b. The adjusted risks of any cancer and obesity-related cancer were significantly lower in cirrhotic versus non-cirrhotic patients who underwent surgery.

c. In cancer-specific models, bariatric surgery was associated with significant risk reductions for colorectal, pancreatic, endometrial, thyroid cancers, hepatocellular carcinoma, and multiple myeloma.

Hence, it was further concluded that "Bariatric surgery was associated with significant reductions in the risks of any cancer and obesity-related cancer in NAFLD patients with severe obesity."

bariatric surgery cancer risk nonalcoholic fatty liver disease Adults Severe Obesity journal of gastroenterology 
Source : Journal of Gastroenterology
Dr. Nandita Mohan
Dr. Nandita Mohan

    BDS, MDS( Pedodontics and Preventive Dentistry)

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

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