Medical Dialogues
  • Dermatology
Login Register
This site is intended for healthcare professionals only
Login Register
  • MD Brand Connect
  • Webinars
  • Vaccine Hub
  • MDTV
    • Breaking News
    • Medical News Today
    • Health News Today
    • Latest
    • Journal Club
    • Medico Legal Update
    • Latest Webinars
    • MD Shorts
    • Health Dialogues
  • Fact Check
  • Health Dialogues
Medical Dialogues
  • Medical News & Guidelines
      • Anesthesiology
      • Cardiology and CTVS
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endocrinology
      • ENT
      • Gastroenterology
      • Medicine
      • Nephrology
      • Neurology
      • Obstretics-Gynaecology
      • Oncology
      • Ophthalmology
      • Orthopaedics
      • Pediatrics-Neonatology
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
      • Laboratory Medicine
      • Diet
      • Nursing
      • Paramedical
      • Physiotherapy
  • Health news
      • Doctor News
      • Government Policies
      • Hospital & Diagnostics
      • International Health News
      • Medical Organization News
      • Medico Legal News
      • NBE News
      • NMC News
  • Fact Check
      • Bone Health Fact Check
      • Brain Health Fact Check
      • Cancer Related Fact Check
      • Child Care Fact Check
      • Dental and oral health fact check
      • Diabetes and metabolic health fact check
      • Diet and Nutrition Fact Check
      • Eye and ENT Care Fact Check
      • Fitness fact check
      • Gut health fact check
      • Heart health fact check
      • Kidney health fact check
      • Medical education fact check
      • Men's health fact check
      • Respiratory fact check
      • Skin and hair care fact check
      • Vaccine and Immunization fact check
      • Women's health fact check
  • AYUSH
    • Ayurveda
    • Homeopathy
    • Siddha
    • Unani
    • Yoga
  • State News
      • Andaman and Nicobar Islands
      • Andhra Pradesh
      • Arunachal Pradesh
      • Assam
      • Bihar
      • Chandigarh
      • Chattisgarh
      • Dadra and Nagar Haveli
      • Daman and Diu
      • Delhi
      • Goa
      • Gujarat
      • Haryana
      • Himachal Pradesh
      • Jammu & Kashmir
      • Jharkhand
      • Karnataka
      • Kerala
      • Ladakh
      • Lakshadweep
      • Madhya Pradesh
      • Maharashtra
      • Manipur
      • Meghalaya
      • Mizoram
      • Nagaland
      • Odisha
      • Puducherry
      • Punjab
      • Rajasthan
      • Sikkim
      • Tamil Nadu
      • Telangana
      • Tripura
      • Uttar Pradesh
      • Uttrakhand
      • West Bengal
  • Medical Education
      • Ayush Education News
      • Dentistry Education News
      • Medical Admission News
      • Medical Colleges News
      • Medical Courses News
      • Medical Universities News
      • Nursing education News
      • Paramedical Education News
      • Study Abroad
  • Industry
      • Health Investment News
      • Health Startup News
      • Medical Devices News
      • Pharma News
      • Pharmacy Education News
      • Industry Perspective
  • MDTV
      • Health Dialogues MDTV
      • Health News today MDTV
      • Latest Videos MDTV
      • Latest Webinars MDTV
      • MD shorts MDTV
      • Medical News Today MDTV
      • Medico Legal Update MDTV
      • Top Videos MDTV
      • Health Perspectives MDTV
      • Journal Club MDTV
      • Medical Dialogues Show
This site is intended for healthcare professionals only
LoginRegister
Medical Dialogues
LoginRegister
  • Home
  • Medical news & Guidelines
    • Anesthesiology
    • Cardiology and CTVS
    • Critical Care
    • Dentistry
    • Dermatology
    • Diabetes and Endocrinology
    • ENT
    • Gastroenterology
    • Medicine
    • Nephrology
    • Neurology
    • Obstretics-Gynaecology
    • Oncology
    • Ophthalmology
    • Orthopaedics
    • Pediatrics-Neonatology
    • Psychiatry
    • Pulmonology
    • Radiology
    • Surgery
    • Urology
    • Laboratory Medicine
    • Diet
    • Nursing
    • Paramedical
    • Physiotherapy
  • Health news
    • Doctor News
    • Government Policies
    • Hospital & Diagnostics
    • International Health News
    • Medical Organization News
    • Medico Legal News
    • NBE News
    • NMC News
  • Fact Check
    • Bone Health Fact Check
    • Brain Health Fact Check
    • Cancer Related Fact Check
    • Child Care Fact Check
    • Dental and oral health fact check
    • Diabetes and metabolic health fact check
    • Diet and Nutrition Fact Check
    • Eye and ENT Care Fact Check
    • Fitness fact check
    • Gut health fact check
    • Heart health fact check
    • Kidney health fact check
    • Medical education fact check
    • Men's health fact check
    • Respiratory fact check
    • Skin and hair care fact check
    • Vaccine and Immunization fact check
    • Women's health fact check
  • AYUSH
    • Ayurveda
      • Ayurveda Giuidelines
      • Ayurveda News
    • Homeopathy
      • Homeopathy Guidelines
      • Homeopathy News
    • Siddha
      • Siddha Guidelines
      • Siddha News
    • Unani
      • Unani Guidelines
      • Unani News
    • Yoga
      • Yoga Guidelines
      • Yoga News
  • State News
    • Andaman and Nicobar Islands
    • Andhra Pradesh
    • Arunachal Pradesh
    • Assam
    • Bihar
    • Chandigarh
    • Chattisgarh
    • Dadra and Nagar Haveli
    • Daman and Diu
    • Delhi
    • Goa
    • Gujarat
    • Haryana
    • Himachal Pradesh
    • Jammu & Kashmir
    • Jharkhand
    • Karnataka
    • Kerala
    • Ladakh
    • Lakshadweep
    • Madhya Pradesh
    • Maharashtra
    • Manipur
    • Meghalaya
    • Mizoram
    • Nagaland
    • Odisha
    • Puducherry
    • Punjab
    • Rajasthan
    • Sikkim
    • Tamil Nadu
    • Telangana
    • Tripura
    • Uttar Pradesh
    • Uttrakhand
    • West Bengal
  • Medical Education
    • Ayush Education News
    • Dentistry Education News
    • Medical Admission News
    • Medical Colleges News
    • Medical Courses News
    • Medical Universities News
    • Nursing education News
    • Paramedical Education News
    • Study Abroad
  • Industry
    • Health Investment News
    • Health Startup News
    • Medical Devices News
    • Pharma News
      • CDSCO (Central Drugs Standard Control Organisation) News
    • Pharmacy Education News
    • Industry Perspective
  • Home
  • Gastroenterology
  • Gastroenterology News
  • IBS Patients Face...

IBS Patients Face Higher Risk of Developing IBD, suggests study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-10-09T21:15:04+05:30  |  Updated On 9 Oct 2025 9:15 PM IST
IBS Patients Face Higher Risk of Developing IBD,  suggests study
  • facebook
  • twitter
  • linkedin
  • whatsapp
  • Telegram
  • Email

Researchers have discovered in a new study that irritable bowel syndrome (IBS) patients have a much greater long-term risk of acquiring inflammatory bowel disease (IBD) than the general population. The study concluded that IBS patients, particularly those with the diarrhea-predominant subtype (IBS-D), had a higher risk of developing ulcerative colitis (UC) or Crohn's disease (CD) in the long run. The study was published in the Journal of Gastroenterology by Huixin S. and colleagues.

IBS and IBD are two prevalent but different gastrointestinal disorders. IBS is defined as a functional disorder in which there is abdominal pain, bloating, diarrhea, or constipation, whereas IBD, encompassing UC and CD, is a chronic inflammatory bowel disease of the gastrointestinal tract with ongoing complications. This UK Biobank large-scale study gives the strongest evidence to date that IBS patients are at a significantly increased risk of developing IBD.

The study team examined 447,631 baseline participants without IBD (2006–2010) for longitudinal cohort analysis and 76,992 participants who filled out the Digestive Health Questionnaire (2017–2018) for cross-sectional analysis. The main outcome in the cohort study was incident new cases of IBD, with Cox proportional hazards models calculating hazard ratios (HRs). In the cross-sectional design, prevalent IBD was taken as the outcome, and logistic regression calculated odds ratios (ORs).

Results

  • During a median follow-up of 14.2 years, the cohort study ascertained 2,916 new cases of IBD, including 2,097 ulcerative colitis (UC) and 1,015 Crohn's disease (CD) cases.

In comparison with non-IBS participants, IBS patients exhibited:

  • 68% increased risk of IBD (HR = 1.68, 95% CI: 1.47–1.92).

  • 60% increased risk of UC (HR = 1.60, 95% CI: 1.36–1.89).

  • 104% increased risk of CD (HR = 2.04, 95% CI: 1.66–2.51).

  • Notably, the risk continued to persist in the long term, with IBS patients continuing to have a 55% increased risk of IBD at 10 years (HR = 1.55, 95% CI: 1.27–1.89).

In cross-sectional analysis, IBS patients had markedly increased odds of IBD:

  • 2.40-fold increased odds of overall IBD (OR = 2.40, 95% CI: 2.14–2.70).

  • 2.18-fold increased odds of UC (OR = 2.18, 95% CI: 1.92–2.48).

  • 3.15-fold increased odds of CD (OR = 3.15, 95% CI: 2.68–3.70).

  • Among the IBS subtypes, the IBS-D group had the highest odds with a 3.72 times higher risk of IBD (OR = 3.72, 95% CI: 3.24–4.28).

This large population study in UK Biobank produces strong evidence that IBS patients, particularly IBS-D, have a significantly higher risk of developing IBD, including UC and CD, compared to the general population. This elevated risk is maintained for more than a decade, supporting the requirement for long-term watchfulness among IBS patients. These findings suggest that IBS might not only be thought of as a functional disorder but also as an occult risk factor for the future development of inflammatory bowel diseases.

Reference:

Song, H., Zhou, Y., Liu, S. et al. Long-term risk of inflammatory bowel disease in patients with irritable bowel syndrome: the cross-sectional and longitudinal relationship. J Gastroenterol (2025). https://doi.org/10.1007/s00535-025-02304-1



Journal of GastroenterologyIBSIBDulcerative colitisCrohn’s diseasegastrointestinal disordersUK BiobankIBS-Dlong-term riskfunctional bowel disorder
Source : Journal of Gastroenterology
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

    Show Full Article
    Next Story

    Editorial

    Indias Unique CV Risk Profile: How to Decode the Role of Aspirin?

    India's Unique CV Risk Profile: How to Decode the Role of Aspirin?

    Vildagliptin-Dapagliflozin FDC Effective in High CV Risk Indian T2DM Patients: Findings from Latest DAa-ViNCI Study

    Vildagliptin-Dapagliflozin FDC Effective in High CV Risk Indian T2DM Patients: Findings from Latest...

    Tirzepatide proves to be more effective than semaglutide- Results of Surmount 5 Trial

    Tirzepatide proves to be more effective than semaglutide- Results of Surmount 5 Trial

    Pneumococcal Vaccination in Hematological Malignancies (HM)-Indian Hematology Expert Consensus 2025

    Pneumococcal Vaccination in Hematological Malignancies (HM)-Indian Hematology Expert Consensus 2025

    Negligence vs Misconduct: Where Do Medical Councils Draw the Line?

    Negligence vs Misconduct: Where Do Medical Councils Draw the Line?

    View All

    Journal Club Today

    Mini Workouts, Major Impact: Study Finds Exercise Snacks Improve Heart Fitness

    Mini Workouts, Major Impact: Study Finds Exercise Snacks Improve Heart Fitness

    View All

    Health News Today

    Health Bulletin 09/October/2025

    Health Bulletin 09/October/2025

    View All
    © 2022 All Rights Reserved.
    Powered By: Hocalwire
    X
    We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok