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  • Mixed Dietary Impact...

Mixed Dietary Impact on IBD: Potatoes Lower Crohn's Risk but Raise Ulcerative Colitis Risk

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-07-02T05:45:30+05:30  |  Updated On 2 July 2025 12:59 PM IST
Mixed Dietary Impact on IBD: Potatoes Lower Crohns Risk but Raise Ulcerative Colitis Risk
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Researchers have found in a large European cohort study that a higher intake of fruits, vegetables, legumes, and potatoes was associated with a reduced risk of Crohn's disease. However, high potato consumption alone was linked to an increased risk of ulcerative colitis. Researchers suggest these findings may be particularly important for children and first-degree relatives of individuals with inflammatory bowel disease. The study was published in The American Journal of Gastroenterology by Meyer A. and colleagues.

The EPIC cohort involved 341,519 participants from Europe and was followed up prospectively for 13.4 years. All subjects had used validated food frequency questionnaires at baseline to record their consumption of fruits, vegetables, legumes, and potatoes. Based on food eating habits, researchers estimated CD and UC risk using Cox proportional hazard models. These models were stratified for center, sex, and age, and adjusted for a number of factors such as smoking status, body mass index (BMI), physical activity, energy intake, educational level, and alcohol use.

Key Findings

149 of the total participants developed Crohn's disease and 379 developed ulcerative colitis during follow-up. The study identified a number of key associations:

• Participants in the highest quartile of total fruit, vegetable, legume, and potato consumption had a 56% lower risk of developing CD compared to those in the lowest quartile (adjusted hazard ratio [aHR] = 0.44; 95% CI: 0.26–0.76; p-trend < 0.01).

• No significant protective association was observed between the same dietary group and UC risk (aHR = 1.07; 95% CI: 0.76–1.50; p-trend = 0.73).

• Individual pooled intake of apple/pear, banana, mushroom, and onion/garlic was associated with a 42% decreased risk of CD comparing the upper to lower quartile (aHR = 0.58; 95% CI: 0.33–1.02; p-trend = 0.03).

• On the other hand, a 51% higher risk of UC was reported in those with the highest quartile of potato intake compared to the lowest (aHR = 1.51; 95% CI: 1.05–2.17).

• A composite diversity score incorporating consumption from fruit, vegetables, legumes, and potatoes had no significant correlation with the risk of either CD or UC.

The research concludes that increased consumption of apple/pear, banana, mushrooms, and onion/garlic lowers the risk of developing Crohn's disease, while increased consumption of potatoes enhances the risk of ulcerative colitis. These findings show the possibilities of specific diet changes in the prevention of inflammatory bowel diseases, especially Crohn's disease, by means of greater consumptions of certain plant foods.

Reference:

Meyer, Antoine MD PhD1,2,a; Carbonnel, Franck MD PhD1,2; Dahm, Christina C PhD3; Halkjær, Jytte PhD4; Tjønneland, Anne MD PhD DMSc4,5; Schulze, Matthias B DrPH6,7; Sacerdote, Carlotta8,9; Tumino, Rosario MD MSc DLSHTM10; Oldenburg, Bas MD PhD11; Huerta, José M PhD12,13; Guevara, Marcela MD PhD14,15,16; Aune, Dagfinn PhD17,18,19; Gunter, Marc J PhD17,20; Heath, Alicia K PhD17; Vineis, Paolo PhD17; Tong, Tammy Y N PhD20; Amiot, Aurélien MD PhD1,2; Chan, Simon S M MB BChir PhD21,22. Fruits, vegetables, legumes and potatoes and risk of Crohn’s disease and ulcerative colitis. The American Journal of Gastroenterology ():10.14309/ajg.0000000000003602, June 24, 2025. | DOI: 10.14309/ajg.0000000000003602

the american journal of gastroenterologyCrohn’s diseaseulcerative colitisfruitsvegetableslegumespotatoesEPIC studydietary diversityinflammatory bowel diseaseCox regressiondiet and IBD risk
Source : The American Journal of Gastroenterology
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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