Serum TSH level may predict survival of hepatitis B related liver failure patients

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-18T20:00:58+05:30 | Updated On 18 Sept 2022 8:01 PM IST

Recently conducted research found that there is a significant correlation between serum Thyroid-stimulating hormone levels and Hepatitis B virus-related Acute-on-Chronic Liver Failure patients' survival rates. The study was published in the journal 'BMC Gastroenterology.'

Acute-on-chronic Liver disease (ACLF) is a complicated condition caused due to acute deterioration of known or unknown chronic liver diseases caused by the Hepatitis B virus. Studies in the past evaluated the association between ACLF and other systemic disorders but there were no studies on the endocrine system. So, researchers from China and U.K. conducted a study to analyze the effect of serum thyroid-stimulation hormone (TSH) levels on the prognosis of patients with hepatitis B virus (HBV)-related ACLF.

A retrospective cohort study was performed on 1,862 patients with HBV-related ACLF. The study data was collected from the "Survival Cohort Study (SCS)" which was registered at ClinicalTrials.gov. Using Cox proportional hazards regression, risk factors associated with 30-day and 90-day survival, hazard ratios (HRs), and 95% confidence intervals (CIs) for TSH were estimated. Obtaining the Area Under the ROC curve (AUROC) analysis, the cut-off values were calculated. Survival was compared between the groups using the log-rank test.

Results:

Elevated TSH level was found to be a significant predictor for 30-day and 90-day survival using Multivariate analysis.
The AUROC of TSH levels for 30-day and 90-day mortality were 0.655 and 0.620, respectively, with the same best cut-off values of 0.261 µIU/mL.
The group with higher TSH levels had higher 30-day and 90-day survival rates in the Log-rank test.
Similar findings were observed in subgroups analysis.
After adjusting for age and other risk factors, the higher level of TSH remained associated with 30-day survival and 90-day survival.

Thus, the researchers concluded that there was a significant correlation between serum TSH level and HBV-related ACLF patients' survival rates and it could be a predicting value for the 30-day and 90-day survival of patients with HBV-related ACLF.

To read the full article, click here: https://doi.org/10.1186/s12876-022-02406-7

Chen JF, Weng WZ, Huang M, et al. The impact of serum thyroid-stimulation hormone levels on the outcome of hepatitis B virus-related acute-on-chronic liver failure: an observational study. BMC Gastroenterol. 2022;22(1):330. Published 2022 Jul 7.

Serum TSHHepatitis B virusAcute on Chronic Liver FailureLiver diseases

Source : BMC Gastroenterology

Dr.Niharika Harsha B

BDS, MDS

Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751