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  • Vebicorvir associated...

Vebicorvir associated with Increased viral suppression with in Hepatitis B infection

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-23T20:30:45+05:30  |  Updated On 23 Sept 2022 8:31 PM IST
Vebicorvir associated with   Increased viral suppression with in Hepatitis B infection
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Vebicorvir was found to increase viral suppression by altering DNA and pregenomic (pg)RNA in Hepatitis B viral infection. It was also found to be safe and tolerable when taken with nucleos(t)ide reverse transcriptase inhibitors as per a study that was published in the Journal of Hepatology.

Total suppression of the hepatitis B virus replication is necessary for finite treatment regimens. Past data has shown persistent viremia during NrtI treatment despite HBV DNA being undetectable as HBV nucleos(t)ide reverse transcriptase inhibitors (NrtIs) do not completely suppress HBV replication. HBV core inhibitors may enhance viral suppression when combined with NrtIs. Vebicorvir (VBR) is a novel inhibitor of the HBV core protein which acts by interfering with two additional steps in HBV replication than NrtIs. Hence researchers conducted a study to evaluate the efficacy and safety of the investigational core inhibitor, vebicorvir (VBR), in virologically- suppressed patients on NrtIs.

Also Read: Consumption of Black tea associated with reduced death risk due to ischemic heart disease and stroke

Non-cirrhotic, NrtI-suppressed patients with chronic HBV were randomized to VBR 300 mg once daily or matching placebo (PBO) for 24 weeks. Treatment was stratified by hepatitis B e antigen (HBeAg) status. The primary endpoint was a change from the Baseline in serum HBeAg or hepatitis B surface antigen (HBsAg) after 24 weeks.

Results

  • 73 patients were enrolled, 47 were HBeAg positive and 26 were HBeAg negative.
  • In HBeAg-positive and -negative patients, there were no differences in the change from Baseline at Week 24 for HBsAg or HBeAg.
  • A greater proportion of patients with detectable HBV DNA at the Baseline achieved undetectable HBV DNA at Week 24 in the VBR+NrtI vs. PBO+NrtI group.
  • In HBeAg-positive patients, a greater change from the Baseline in HBV pregenomic (pg)RNA was observed at Week 24 with VBR+NrtI vs. PBO+NrtI.
  • Treatment-emergent adverse events (TEAEs) in VBR+NrtI patients included upper respiratory tract infection, nausea, and pruritus.
  • No serious adverse events, Grade 4 TEAEs, or deaths were reported.
Also Read: Coffee intake associated with low liver stiffness but not steatosis

Thus, the researchers concluded from their 24-week study that VBR+NrtI demonstrated a favorable safety and tolerability profile and also achieved enhanced viral suppression.

For full reading: https://doi.org/10.1016/j.jhep.2022.04.005

Yuen MF, Agarwal K, Ma X, et al. Safety and efficacy of vebicorvir in virologically suppressed patients with chronic hepatitis B virus infection. J Hepatol. 2022;77(3):642-652.

Hepatitis B virusVebicorvirHBV core proteinnucleotide reverse transcriptase inhibitorsviremiahepatitis B e antigenhepatitis B surface antigenupper respiratory tract infectionviral antigen
Source : Jounral of Hepatology
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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