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  • Vedolizumab associated...

Vedolizumab associated with Higher Risk of Treatment Failure in Older IBD Patients: JAMA

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-10-05T20:00:56+05:30  |  Updated On 5 Oct 2022 8:01 PM IST
Vedolizumab associated with Higher Risk of Treatment Failure in Older IBD Patients: JAMA
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Vedolizumab in older IBD patients is tied with a higher risk for treatment failure according to a recent study published in the JAMA Network Open.

Observational comparative effectiveness studies can inform the positioning of biologic therapies for older patients with inflammatory bowel disease (IBD) who are underrepresented in clinical trials.

A study was conducted to compare the effectiveness and safety of vedolizumab vs tumour necrosis factor (TNF) for older patients with IBD.

This active comparator, new-user design, and comparative effectiveness study were conducted between January 1, 2005, and December 31, 2018, among 754 older patients (aged ≥50 years) with IBD from the Danish National Patient Register. The mean follow-up after treatment initiation took place at 32 to 40 weeks. Statistical analysis was performed from February 1 to April 27, 2022. The primary effectiveness outcome was treatment failure, defined as the composite risk of IBD-related hospitalization, IBD-related surgery, or a new corticosteroid prescription more than 6 weeks after initiation of treatment with biologic therapy. Secondary effectiveness outcomes were time to each individual component of the composite effectiveness outcome. The primary safety outcome was the risk of serious infections, defined as infections requiring hospitalization. A 1:1 propensity score-matched analysis was conducted, accounting for patient-, disease-, and treatment-associated factors.

The Results:

  • The study compared 377 older patients with IBD with incident use of vedolizumab vs 377 patients with incident use of TNF antagonists.
  • Overall, vedolizumab was associated with an increased risk of treatment failure compared with TNF antagonists and IBD-related major abdominal surgery
  • In subgroup analysis by IBD phenotype, among patients with Crohn disease, vedolizumab was associated with a 77% higher risk of treatment failure
  • There was no significant difference in the risk of serious infections, overall and by IBD phenotype.

Thus, in this comparative effectiveness study of older patients with IBD, vedolizumab was associated with a higher risk of treatment failure compared with TNF antagonists, particularly among patients with Crohn disease, without offering a significant safety advantage.

Reference:

Singh S, Iversen AT, Allin KH, Jess T. Comparative Outcomes and Safety of Vedolizumab vs Tumor Necrosis Factor Antagonists for Older Adults With Inflammatory Bowel Diseases. JAMA Netw Open. 2022;5(9):e2234200. doi:10.1001/jamanetworkopen.2022.34200

Keywords:

Singh S, Iversen AT, Allin KH, Jess T, comparative, outcomes, safety, vedolizumab, tumor Necrosis, Factor, Antagonists, Older, Adults, Inflammatory, Bowel Diseases, JAMA Netw Open.


jama network openinflammatory boweltumor necrosis factorVedolizumab
Source : JAMA Network Open
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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