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  • Vitamin D Deficiency...

Vitamin D Deficiency may be Linked to development of Ulcerative Colitis

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-10-30T11:00:36+05:30  |  Updated On 30 Oct 2023 11:29 AM IST
Vitamin D Deficiency may be Linked to development of Ulcerative Colitis
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A recent groundbreaking study found that Ulcerative colitis has a direct correlation with serum vitamin D levels. Researchers found in a study that ulcerative colitis patients have abnormally lower levels of vitamin D when compared to healthy controls. The study results were published in the European Journal of Gastroenterology & Hepatology.

Also Read: Multimatrix Mesalamine effective in treatment of paediatric Ulcerative Colitis

Ulcerative colitis (UC) is a condition marked by chronic inflammation of the colon and rectum. Over the years, its incidence has been steadily rising, making it a matter of concern for both patients and healthcare professionals. Researchers have observed that many UC patients tend to have abnormal levels of vitamin D, prompting them to investigate the potential association between vitamin D and UC in a systematic review and meta-analysis. Researchers from the Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China conducted a systematic review and meta-analysis of various case-control studies to investigate the association between vitamin D levels and ulcerative colitis.

The research team conducted a comprehensive review, scouring databases like PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database (VIP) from their inception until December 2022. They selected case-control studies that compared vitamin D levels between UC patients and healthy individuals. To analyze the data, they employed well-established software, including Review Manager 5.4 and Stata 17.0.

Results:

  • After thorough analysis, the team examined sixteen eligible observational studies encompassing a total of 2,234 subjects, consisting of 987 UC patients and 1,247 controls.
  • The results of this meticulous investigation were striking.
  • They found that UC patients exhibited significantly lower serum vitamin D levels compared to their healthy counterparts.
  • In precise numbers, the standardized mean difference (SMD) indicated a significant disparity of -0.83 with a 95% confidence interval (CI) ranging from -1.18 to -0.48.
  • Furthermore, vitamin D deficiency, a prevalent concern in the context of UC, was addressed when five studies reported that vitamin D deficiency was noticeably more common in the UC group when compared to the healthy control group.
Also Read: FDA approves etrasimod for moderate to severe Ulcerative Colitis

The research findings strongly suggest a direct correlation between vitamin D levels and UC. The significantly lower vitamin D levels in UC patients compared to healthy individuals underscore the importance of further research in this domain. Understanding this connection could potentially lead to innovative strategies for UC management, offering hope for patients grappling with this challenging condition. It is clear that vitamin D and its potential role in the onset and progression of UC warrant continued exploration and consideration by healthcare professionals and researchers alike.

Further reading: Liu, Chenyu; Liu, Xin; Shi, Haitao; Chen, Fenrong; Sun, Linlang; Gao, Xin; Wang, Yan. The correlation between serum 25-hydroxyvitamin D level and ulcerative colitis: a systematic review and meta-analysis. European Journal of Gastroenterology & Hepatology. DOI: 10.1097/MEG.0000000000002670

European Journal of Gastroenterology & HepatologyUlcerative ColitisVitamin D levelsUCGastric DiseasesStomach Ulcer
Source : European Journal of Gastroenterology & Hepatology
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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