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Compensatory reserve index can predict recurrent shock in severe dengue: Study
Vietnam: In patients with severe dengue, compensatory reserve Index (CRI) may be a useful non-invasive method for monitoring intravascular volume status, states a recent study published in the journal BMC Medicine. It can predict re-shock onset in severe dengue within 12 h of measurement.
The findings imply that CRI can assist in the early detection of re-shock in dengue patients admitted to ICU and could guide individualized fluid resuscitation strategies in these patients.
Dengue shock syndrome (DSS), one of the major clinical phenotypes of severe dengue, is defined by significant plasma leak, leading to intravascular volume depletion and eventually cardiovascular collapse. The compensatory reserve index (CRI) is a new physiological parameter that is derived from feature analysis of the pulse arterial waveform that tracks real-time changes in central volume.
Based on the above, Huynh Trung Trieu, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, and colleagues investigated the usefulness of CRI for predicting recurrent shock in severe dengue patients admitted to the ICU.
For this purpose, the researchers performed a prospective observational study in the pediatric and adult intensive care units at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. In addition to the continuous recording of the arterial waveform using pulse oximetry, the patients were monitored with hourly clinical parameters and vital signs. The waveform data was wirelessly transmitted to a laptop where it was synchronized with the patient's clinical data.
The researchers recruited 103 patients with suspected severe dengue. Sixty-three patients had the minimum required dataset for analysis. The median age was 11 years.
Following were the key findings of the study:
- CRI had a negative correlation with heart rate and moderate negative association with blood pressure.
- CRI was found to predict recurrent shock within 12 h of being measured (OR 2.24).
- The median duration from CRI measurement to the first recurrent shock was 5.4 h (IQR 2.9–6.8).
- A CRI cutoff of 0.4 provided the best combination of sensitivity and specificity for predicting recurrent shock (0.66 and 0.86 respectively).
To conclude, "CRI is a useful non-invasive method for monitoring intravascular volume status in patients with severe dengue."
Reference:
Trieu, H.T., Khanh, L.P., Ming, D.K.Y. et al. The compensatory reserve index predicts recurrent shock in patients with severe dengue. BMC Med 20, 109 (2022). https://doi.org/10.1186/s12916-022-02311-6
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751