New blood test could measure dietary intake of fats accurately
Researchers at McMaster University have developed a reliable and accurate blood test to track fat intake in an individual. The test detects specific non-esterified fatty acids (NEFAs), a type of circulating free fatty acid that can be measured using a small volume of blood sample.
This tool will help establish reliable guidelines as it will obviate human error and selective reporting and could guide public health policy on healthy eating.
The research has been published in the Journal of Lipid Research.
"Epidemiologists need better ways to reliably assess dietary intake when developing nutritional recommendations," says Philip Britz-McKibbin, professor in the Department of Chemistry & Chemical Biology at McMaster University and lead author of the study.
"The food we consume is highly complex and difficult to measure when relying on self-reporting or memory recall, particularly in the case of dietary fats. There are thousands of chemicals that we are exposed to in foods, both processed and natural," he says.
The study was a combination of two research projects Britz-McKibbin conducted with Sonia Anand in the Department of Medicine and Stuart Phillips in the Department of Kinesiology.
Researchers first assessed the habitual diet of pregnant women in their second trimester, an important development stage for the fetus. The women, some of whom were taking omega-3 fish oil supplements, were asked to report on their average consumption of oily fish and full-fat dairy and were then tested with the new technology. Their study also monitored changes in omega-3 NEFAs in women following high-dose omega-3 fish oil supplementation as compared to a placebo.
Researchers were able to prove that certain blood NEFAs closely matched the diets and/or supplements the women had reported, suggesting the dietary biomarkers may serve as an objective tool for assessment of fat intake.
"Fat intake is among the most controversial aspects of nutritional public health policies given previously flawed low-fat diet recommendations, and the growing popularity of low-carb/high-fat ketogenic based diets" says Britz-McKibbin. "If we can measure it reliably, we can begin to study such questions as: Should pregnant women take fish oil? Are women deficient in certain dietary fats? Does a certain diet or supplement lead to better health outcomes for their babies?"
Researchers plan to study what impact NEFAs and other metabolites associated with dietary exposures during pregnancy, might have on childhood health outcomes in relation to the obesity, metabolic syndrome and chronic disease risk later in life.
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Sandi M. Azab, Russell J. de Souza, Koon K. Teo, Sonia S. Anand, Natalie C. Williams, Jordan Holzschuher, Chris McGlory, Stuart M. Phillips, Philip Britz-McKibbin. Serum non-esterified fatty acids have utility as dietary biomarkers of fat intake from fish, fish oil and dairy in women. Journal of Lipid Research, 2020; jlr.D120000630 DOI: 10.1194/jlr.D12000063