Acrokeratosis verruciformis of Hopf: dermoscopic and histopathological study- Acrokeratosis verruciformis of Hopf (AVH) is an autosomal dominant genodermatosis. It is caused by a mutation in the ATP2A2 gene, located on chromosome 12q24. Both AVH and Darier disease are believed to be allelic disorders. Familial cases of AVH usually have early onset either at birth or childhood, while sporadic cases usually present later in life. Recently dermoscopy of AVH has been described in Clinical and Experimental Dermatology journal.
Two siblings, a 7-year-old boy and a 5-year-old girl born to nonconsanguineous parents presented with a 4-year history of multiple, asymptomatic, skin-coloured papules. The lesions were present mainly over the dorsal aspects of the forearms in the boy and ventral aspect of the forearm and the antecubital fossa in the girl.
For more details check out the link below: