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Buccally absorbed cannabidiol safe and effective for managing pain after rotator cuff surgery
Cannabidiol is effective in improving immediate post-operative pain following arthroscopic rotator cuff repair, according to research presented today at the American Orthopaedic Society of Sports Medicine 2022 Annual Meeting.
Michael J. Alaia, MD, NYU Langone Health in New York City, sought to determine if CBD could be safe and effective as a pain medicine for patients after rotator cuff surgery. Dr. Alaia and colleagues established a multi-center, placebo-controlled, randomized, double-blinded trial conducted on patients undergoing rotator cuff repair. Dr.
Alaia enrolled 80 patients from 18 to 75 years of age and one group received 25mg of CBD (Oravexx, Orcosa Pharmaceuticals, USA) TID if patients weighed less than 176 pounds (80kg) and 50mg of CBD if they weighed more than 176 pounds (80kg) for 14 days, and the control group was given a placebo.
Currently, cannabidiol is FDA approved for the treatment of some seizures and other studies have suggested the therapy may help treat anxiety, cognition, and movement disorders though research has yet to prove it can be used to treat these disorders.
Patients were followed-up on days one, two, seven, and 14, and the Visual Analog Scale (VAS) for pain, opioid consumption, and satisfaction with pain control were recorded. The (VAS) is a validated, subjective measure for acute and chronic pain.
Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between "no pain" and "worst pain." Additionally, liver function tests (LFT) were done on days seven and 14 to assess safety, and nausea was monitored.
On day one, the VAS pain score was significantly lower in those receiving CBD (4.1 +- 3.0 vs 6.0 +- 3.1, p = 0.01), which also meets VAS MCID for shoulder arthroscopy (1.2-1.4). Patient satisfaction with pain control trended towards significance favoring the CBD group (72% vs 60%, p = 0.072). However, there were no statistically significant differences in opioid consumption (16.4mme +- 12.7 vs 20.6mme +- 14.4, p = 0.186), which was relatively small in both groups.
Notably, patients receiving 50 mg of CBD reported lower VAS scores at day 1 (3.9 +- 3.3 vs 4.6 +-2.5 +- 6.0 +- 3.1, p = 0.0394) and higher satisfaction with pain control at day 1 and 2 (8.1 +- 2.3, 5.8 +- 3.3, 5.9 vs 3.6, p = 0.0175 | 7.8 +- 1.8 vs 6.3 +- 3.0 6.0 +- 3.2, p = 0.05) compared to those receiving 25 mg of CBD and control group respectively. On day sever and day 14, there were no statistically significant differences in VAS score, opioid consumption, or patient satisfaction with pain control (p>0.05 for all). There were no significant differences in nausea or LFTs post-operatively (p > 0.05).
"Based on our findings, CBD is safe and effective in reducing pain in the immediate peri-operative period following rotator cuff repair and should be considered in postoperative multimodal pain control," Dr. Alaia reported.
Reference:
"Buccally absorbed cannabidiol is safe and effective for pain management after rotator cuff surgery";AMERICAN ORTHOPAEDIC SOCIETY FOR SPORTS MEDICINE, MEETING- American Orthopaedic Society for Sports Medicine Annual Meeting.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751