Dexamethasone improves survival in serious cases of Covid 19: Study
United Kingdom- Researchers in England say they have the first evidence that a drug can improve COVID-19 survival.
UK experts have found that low-dose dexamethasone is a major breakthrough in the fight against the deadly virus COVID 19.
Dexamethasone cuts the risk of death by a third for patients on ventilators and for those on oxygen, it cut deaths by a fifth.
The drug is a part of recovery Trial a national clinical trial that aims to identify treatments that may be beneficial for people hospitalised with suspected or confirmed COVID-19
Results were announced Tuesday and researchers said they would publish them soon. The study is a large, strict test that randomly assigned 2,104 patients to get the drug and compared them with 4,321 patients getting only usual care.
The drug was given either orally or through an IV. It reduced deaths by 35% in patients who needed treatment with breathing machines and by 20% in those only needing supplemental oxygen. It did not appear to help less ill patients.
"This is an extremely welcome result," one study leader, Peter Horby of the University of Oxford, said in a statement. "The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide."
This is the same study that earlier this month showed the malaria drug hydroxychloroquine was not working against the coronavirus. The study enrolled more than 11,000 patients in England, Scotland, Wales and Northern Ireland who were given either standard of care or that plus one of several treatments: the HIV combo drug lopinavir-ritonavir, the antibiotic azithromycin; the steroid dexamethasone, the anti-inflammatory drug tocilizumab, or plasma from people who have recovered from COVID-19 that contains antibodies to fight the virus.
Research is continuing on the other treatments. The research is funded by government health agencies in the United Kingdom and private donors including the Bill and Melinda Gates Foundation.