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  • Endocrine therapy...

Endocrine therapy break for seeking pregnancy did not impact outcomes in breast cancer patients: NEJM

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-05-10T10:00:25+05:30  |  Updated On 10 May 2023 4:19 PM IST
Endocrine therapy break for seeking pregnancy did not impact outcomes in breast cancer patients: NEJM
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A new study published in the New England Journal Of Medicine suggests that temporary suspension of hormone medication to seek pregnancy did not give a higher short-term risk of breast cancer events, including distant recurrence, than the external control cohort among select women with prior hormone receptor-positive early breast cancer.

There is a dearth of prospective evidence on the risk of recurrence in women with hormone receptor-positive early breast cancer who temporarily quit endocrine therapy to try to conceive. As a result, Ann Partridge and colleagues undertook this research to examine recurrence after temporarily discontinuing medication.

Researchers performed a single-group experiment to assess the brief suspension of adjuvant endocrine treatment to seek conception in young women with prior breast cancer. Eligible women were 42 or younger, had stage I, II, or III illness, had undergone adjuvant endocrine treatment for 18 to 30 months, and wanted to have a baby. The number of breast cancer occurrences during follow-up was the major end point. The primary analysis was scheduled for 1600 patient-years of follow-up. The incidence of 46 breast cancer incidents over this time period met the predetermined safety threshold. The results of breast cancer in this treatment-interrupted group were compared to those in an external control cohort of women who would have satisfied the admission requirements for the study.

The key findings of this study were:

1. The median age of the 516 women was 37, the median time from breast cancer diagnosis to enrolment was 29 months, and 93.4% had stage I or II illness.

2. 368 (74.0%) of the 497 women monitored for pregnancy status had at least one pregnancy, and 317 (63.8%) had at least one live birth.

3. There were 365 babies born in total. 44 patients experienced a breast cancer incident during 1638 patient-years of follow-up (median follow-up, 41 months), a result that did not surpass the safety threshold.

4. The 3-year incidence of breast cancer events in the treatment-interrupted group was 8.9% and 9.2% in the control cohort.

There is no increase in the short-term risk of breast cancer events among select women with past hormone receptor-positive early breast cancer when endocrine medication is temporarily interrupted to seek pregnancy.

Reference:

Partridge, A. H., Niman, S. M., Ruggeri, M., Peccatori, F. A., Azim, H. A., Jr., Colleoni, M., Saura, C., Shimizu, C., Sætersdal, A. B., Kroep, J. R., Mailliez, A., Warner, E., Borges, V. F., Amant, F., Gombos, A., Kataoka, A., Rousset-Jablonski, C., Borstnar, S., Takei, J., … Pagani, O. (2023). Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer. In New England Journal of Medicine (Vol. 388, Issue 18, pp. 1645–1656). Massachusetts Medical Society. https://doi.org/10.1056/nejmoa2212856

The New England Journal of Medicinebreast cancersendocrine therapy
Source : New England Journal of Medicine
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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