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  • Exercise and lower...

Exercise and lower extremity revascularization benefit peripheral artery disease; finds study

Written By : Dr Satabdi Saha |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-04-21T07:15:15+05:30  |  Updated On 21 April 2021 7:15 AM IST
Exercise and lower extremity revascularization benefit peripheral artery disease; finds study
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Exercise therapy (ET) and lower extremity revascularization , together, improves walking performance better than either therapy alone, for the treatment of peripheral artery disease (PAD), suggests the findings of a recent study .The findings have been published in Journal of American College of Cardiology.

PAD , Peripheral artery disease is associated with functional limitations, significant morbidity, and increased risks of cardiac and limb ischemic events .Despite numerous studies examining these treatment modalities, it remains unclear which treatment, if any, should be favored in a typical patient with claudication. The goal of this structured review is to improve the clinician's understanding of the effectiveness of these preferred management interventions in this highly prevalent and limiting disorder and to highlight areas for future research endeavors.

As for the study design,researchers searched publication databases through 2020 for publications on ET and LER in the treatment of PAD. A total of 47 articles were included in this analysis, inclusive of a median 100 participants aged 38 to 86 years (64% men). Most of the studies had follow-ups ranging between 6 and 18 months, which is within this range commonly used for such therapies. Interventions included ET compared with control (n=27), LER compared with control (n=12), ET with LER (n=8), LER and ET compared with ET alone (n=6), and LER and ET compared with LER alone (n=6).

Data analysis revealed the following facts.

  • Combination therapy was superior to ET alone in improving walking performance at 6-12 (B Grade), 12-18 (B Grade), and >18 (C Grade) months and at deferring claudication onset at 6 -12 (C Grade) and 12-18 (B Grade) months.
  • The combination therapy compared with LER alone was superior at improving walking speed at less than 6 (B) and 6 to 12 (C grade) months and was better at deferring claudication onset at less than 6 months (C grade).

Key highlights from the results are as follows-

  • In the management of symptomatic peripheral artery disease, aerobic exercise therapy and lower extremity revascularization are the mainstays of therapy.
  • In this structured review, the most effective therapies, with 6 to 18 months of follow-up, indicated that exercise therapy and lower extremity revascularization each independently improve peak walking performance.
  • The combination of therapies was superior to either therapy alone and may decrease the need for subsequent revascularization.
  • Further research is needed to evaluate the long-term durability of these interventions, their impacts on subsequent invasive procedures, and predictors of response.

For full article follow the link: Biswas MP, Capell WH, McDermott MM, et al. Exercise Training and Revascularization in the Management of Symptomatic Peripheral Artery Disease. J Am Coll Cardiol Basic Trans Science. 2021;6(2):174-188. doi:10.1016/j.jacbts.2020.08.012

Primary source: Journal of American College of Cardiology: Basic to Translational Science.


exercise therapylower artery revascularisationCombination Therapyjournal of american college of cardiology
Source : Journal of American College of Cardiology
Dr Satabdi Saha
Dr Satabdi Saha

    Dr Satabdi Saha (BDS, MDS) is a practicing pediatric dentist with a keen interest in new medical researches and updates. She has completed her BDS from North Bengal Dental College ,Darjeeling. Then she went on to secure an ALL INDIA NEET PG rank and completed her MDS from the first dental college in the country – Dr R. Ahmed Dental College and Hospital. She is currently attached to The Marwari Relief Society Hospital as a consultant along with private practice of 2 years. She has published scientific papers in national and international journals. Her strong passion of sharing knowledge with the medical fraternity has motivated her to be a part of Medical Dialogues.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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