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Fremanezumab helps prevent chronic migraine and improve QOL, claims study
Recent study has highlighted that fremanezumab demonstrated efficacy in the preventive treatment of chronic migraine and reduced headache impact in patients with comorbid depression. The findings have been put forth in Headache, The Journal of Head and Face Pain.
Fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene–related peptide, has been approved for the preventive treatment of migraine in adults. CM and depression are highly comorbid.Researchers aimed to evaluate the efficacy of fremanezumab in patients with chronic migraine (CM) and moderate to severe depression.
For the study design, the 12-week, Phase 3 HALO trial randomized patients with CM to fremanezumab quarterly (675 mg/placebo/placebo), fremanezumab monthly (675/225/225 mg), or placebo was selected. Post hoc analyses evaluated the effects of fremanezumab in patients with moderate to severe depression (baseline 9-item Patient Health Questionnaire sum score ≥10) on monthly number of headache days of at least moderate severity; monthly migraine days; Patient Global Impression of Change (PGIC); 6-item Headache Impact Test (HIT-6) scores; and depression.
Results put forth some key facts.
- For the 219/1121 (19.5%) patients with moderate to severe depression at baseline, fremanezumab was associated with a significant reduction in monthly number of headache days of at least moderate severity for active treatment versus placebo (least-squares mean change ± standard error for quarterly dosing: −5.3 ± 0.77; for monthly dosing: −5.5 ± 0.72; and for placebo: −2.2 ± 0.81; both p < 0.001).
- More patients achieved a ≥50% reduction in headache days of at least moderate severity with fremanezumab (quarterly: 31/78 [39.7%]; monthly: 39/96 [40.6%]) than placebo (9/67 [13.4%]; both p < 0.001).
- Compared with placebo, fremanezumab improved PGIC and HIT-6 scores.
" Fremanezumab demonstrated a significant treatment benefit over placebo in reducing the monthly average number of headache days of at least moderate severity and migraine days in patients with CM and comorbid moderate to severe depression. Greater improvements in HRQoL, headache impact, and patient-reported overall health status were also seen with fremanezumab than with placebo. Fremanezumab may benefit patients with migraine and comorbid depression by reducing the frequency of migraine and headache days, decreasing disability, and improving HRQoL."the team opined.
For full article follow the link: https://doi.org/10.1111/head.14097
Source: Headache
Dr Satabdi Saha (BDS, MDS) is a practicing pediatric dentist with a keen interest in new medical researches and updates. She has completed her BDS from North Bengal Dental College ,Darjeeling. Then she went on to secure an ALL INDIA NEET PG rank and completed her MDS from the first dental college in the country – Dr R. Ahmed Dental College and Hospital. She is currently attached to The Marwari Relief Society Hospital as a consultant along with private practice of 2 years. She has published scientific papers in national and international journals. Her strong passion of sharing knowledge with the medical fraternity has motivated her to be a part of Medical Dialogues.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751