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  • High-Dose Influenza...

High-Dose Influenza Vaccine Reduces Hospitalization in Seniors, claims study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-05-27T10:00:34+05:30  |  Updated On 27 May 2024 12:21 PM IST
Non-Communicable Diseases
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Researchers have found that high-dose influenza vaccine (HD-IV) significantly reduces the rates of pneumonia and influenza (P&I) and all-cause hospitalizations in adults aged 65 and older compared to the standard-dose influenza vaccine (SD-IV). This study provides crucial insights into the relative effectiveness of HD-IV, particularly for severe clinical outcomes. This study was published in the Journal Of Infection by Kristoffer G. and colleagues.

Influenza poses a significant health risk, especially for older adults, leading to severe complications such as pneumonia and increased hospitalizations. This study aimed to summarize the current evidence on the effectiveness of HD-IV versus SD-IV in mitigating these severe outcomes in the elderly population. The study's objective was to assess whether HD-IV offers superior protection against P&I hospitalizations, all-cause hospitalizations, and all-cause death compared to SD-IV.

A prespecified meta-analysis was conducted, encompassing five randomized controlled trials with a total of 105,685 participants aged 65 years and older. The analysis evaluated the relative vaccine effectiveness (rVE) of HD-IV versus SD-IV using fixed-effects models with the inverse variance method. The primary outcomes measured were the rates of P&I hospitalization, all-cause hospitalization, and all-cause death

• HD-IV was associated with a 23.5% reduction in P&I hospitalizations compared to SD-IV (rVE: 23.5%, [95% CI: 12.3% to 33.2%]).

• The rate of all-cause hospitalizations was reduced by 7.3% in the HD-IV group compared to the SD-IV group (rVE: 7.3%, [95% CI: 4.5% to 10.0%]).

• No significant difference was observed in all-cause death rates between HD-IV and SD-IV (rVE: 1.6%, [95% CI: -2.0% to 5.0%]).

The findings suggest that HD-IV is more effective than SD-IV in reducing severe clinical outcomes like P&I and all-cause hospitalizations in adults aged 65 and older. The consistent protection across different subgroups underscores the importance of considering HD-IV for elderly populations, especially during flu seasons with high rates of complications. Despite the lack of significant difference in all-cause death rates, the reduction in hospitalization rates is a compelling argument for the use of HD-IV.

Sensitivity analyses, which omitted trials with participants sharing the same comorbidity, trials with 100 or more events, and using random-effects models, yielded comparable estimates for all outcomes, reinforcing the robustness of the findings.

This study concludes that HD-IV significantly reduces the incidence of P&I and all-cause hospitalizations compared to SD-IV in adults aged 65 and older. While no significant difference was observed in all-cause death rates, the evidence supports the use of HD-IV to mitigate severe clinical outcomes in the elderly. These findings, drawn from several randomized trials, highlight the potential benefits of HD-IV and suggest the need for further research in fully powered, individually randomized trials.

Reference:

Skaarup, K. G., Lassen, M. C. H., Modin, D., Johansen, N. D., Loiacono, M. M., Harris, R. C., Lee, J. K. H., Dufournet, M., Vardeny, O., Peikert, A., Claggett, B., Solomon, S. D., Jensen, J. U. S., & Biering-Sørensen, T. (2024). The relative vaccine effectiveness of high-dose vs standard-dose influenza vaccines in preventing hospitalization and mortality: A meta-analysis of evidence from randomized trials. The Journal of Infection, 106187, 106187. https://doi.org/10.1016/j.jinf.2024.106187

Journal Of InfectionHigh-dose influenza vaccineHD-IVstandard-dose influenza vaccineSD-IVpneumoniainfluenzahospitalizationselderlyvaccine effectivenessclinical outcomes
Source : Journal Of Infection
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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