Increasing number and intensity of steps taken daily can reduce risk of several Chronic Diseases

The association between physical activity and human disease has not been examined using commercial devices linked to electronic health records.

Vanderbilt University Medical Center researchers have found in a new study that using a wearable activity tracker to count and increase the number and intensity of steps taken daily can reduce the risk of several common, chronic diseases, including diabetes, hypertension, obesity, and sleep apnea.

The research has been published in the journal Nature Medicine.

Integrating data from commercial wearable activity trackers and health monitors into the electronic health record (EHR) may be valuable to physicians, who could use it to tailor physical activity to patients' clinical characteristics and risk profiles, said the paper's corresponding author, Evan Brittain, MD, MSCI, associate professor of Medicine.

The study analyzed an average of four years of activity and health data from more than 6,000 participants in the federal All of Us precision medicine research initiative who wore Fitbit activity trackers at least 10 hours a day, and who provided access to their EHRs.

The researchers compared the incidence of various diseases across the entire human phenome of observable traits and conditions in the general population to Fitbit-wearing participants in the study, which was conducted between May 30, 2018, and April 1, 2021.

Taking more than 8,200 steps per day (about 4 miles) was found to protect against obesity, sleep apnea, gastroesophageal reflux disease, and major depressive disorder. The data suggests that overweight individuals can reduce their risk of becoming obese by 64% if they increase their daily steps from 6,000 to 11,000.

Risk declined for most conditions as the number of steps increased, except for the risk of hypertension and diabetes, which did not decline further after participants reached about 8,000 to 9,000 steps per day.

Study participants ranged in age from 41 to 67 and had body mass indices (BMIs) ranging from 24.3 (healthy weight) to 32.9 (obese). Seventy-three percent of participants were females, 84% were white, and 71% had a college degree.

Fitbit-wearing participants tend to be more active than the average adult, yet "the fact that we were able to detect robust associations between steps and … disease in this active sample suggests even stronger associations may exist in a more sedentary population," the researchers said.

While further study is needed in a more diverse and representative population, these findings provide a necessary first step toward the development of personalized activity prescriptions, they added. Wearables can encourage patients to exercise by enabling them to set, measure and track their fitness goals.

Reference:

Master, H., Joshua Beckman, Robert Carroll, Karthik Natarajan PhD, Annis, J., Huang, S. et al. Association of step counts over time with the risk of chronic disease in the All of Us Research Program. Nat Med (2022). https://doi.org/10.1038/s41591-022-02012-w