Novel insecticide paint may help curb outbreaks of Malaria, Zika and dengue fever: Study

Spain: A recent study published in Frontiers in Tropical Diseases has suggested insecticide paints to be an effective innovation strategy for mosquito control.

"The strategy could be implemented as a reinforcement of the measures carried out by the vector control program in the city of Praia and throughout the country," the researchers wrote.

Malaria and other illnesses caused by parasites, viruses, and bacteria transmitted by organisms that spread infectious pathogens account for more than 17% of all infectious diseases worldwide. These vector-borne diseases, typically transmitted by insects like mosquitoes, flies, and ticks, disproportionally affect the poorest populations in tropical and subtropical regions.

In Cabo Verde, an island nation off west Africa, vector-borne disease has been prevalent for centuries, in part due to the island’s geographical location and climate. Now, researchers in Cabo Verde and Spain set out to test the efficacy of three insecticide paint formulations to reinforce the existing national program aiming to minimize the occurrence of disease outbreaks.

“Here we show that VESTA insecticide paint is effective at killing Aedes aegypti, the yellow fever mosquito, in the city of Praia for at least one year,” said lead author Dr Lara Ferrero Gómez, who coordinates a research group on tropical diseases at the Jean Piaget University of Cabo Verde. “We also found it has good acceptance in the population, with 98% confirming the decrease in mosquitoes in their residences after paint application.”

Mosquito control for up to a year

In a large-scale field trial, trained volunteers painted 228 houses in two Praia neighborhoods that are particularly vulnerable to diseases transmitted by mosquitoes. This is due to insufficient drainage which leads to flooding in the rainy season and poor wastewater management. Additionally, many residences in Cabo Verde store water due to insufficient and disrupted water supply, and water storage is often unsafe.

After one, three, six, and 12 months, WHO cone bioassays were conducted at two randomly selected houses in each neighborhood. “Bioassays record the mortality of A. aegypti mosquitoes after exposing them for half an hour to the insecticidal paint. This allows us to directly evaluate the effectiveness of the insecticidal paint,” Ferrero Gómez explained.

All three insecticide paint mixtures lead to complete mortality of A. aegypti mosquitoes one month after the houses were painted. Three months after painting, all formulations still exceeded the WHO efficiency threshold, which lies at 80%. At month six, two formulations fell below this threshold. The VESTA formulation, however, also met WHO requirements at months six and 12. “The paint works by releasing very small quantities of insecticide over a long period, which makes it more sustainable and eco-friendlier,” Ferrero Gómez pointed out.

The researchers did not register any serious effects of the paint on residents’ health. Adverse effects reported by few residents included mild eye or nose irritation (10%) and headache (4%).

Malaria free – what’s next?

At the beginning of the year, Cabo Verde was the third country in Africa to be declared free of Malaria by the WHO. The challenge to stop its reoccurrence, however, remains. The researchers said that insecticidal paint is also a promising strategy to strengthen the prevention and control of malaria cases at a household level since insecticide paint is effective for any type of vector disease transmitted by mosquitos, not just zika and dengue fever.

While the researchers face certain limitations, such as the need to meticulously apply the paint in two layers to ensure it does not lose its effectiveness, the TINTAEDES project is expected to extend to more locations across Praia, which is a hotspot for vector-borne diseases, as well as across all of Cabo Verde.

Reference:

Lara Ferrero Gómez, Hélio D. Ribeiro Rocha, Ignacio Gil Torró, Irene Serafín Pérez, Deinilson Conselheiro Mendes, Keily L. Fonseca Silva, Davidson D. Sousa Rocha Monteiro, Jailson P. Tavares Dos Reis, Silvânia Veiga Leal, Mendez, Basilio Valladares Hernández, Insecticide paints: a new community strategy for controlling dengue and zika mosquito vectors in Cabo Verde, Frontiers in Tropical Diseases, https://doi.org/10.3389/fitd.2024.1321687.