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Once Weekly Mazdutide effectvely reduced body weight in obese individuals: NEJM

A new study published in The New England Journal of Medicine showed that once weekly mazdutide at a dosage of 4 mg or 6 mg for 32 weeks resulted in clinically significant weight loss in Chinese adults who were overweight or obese.
This research randomly assigned adults aged 18 to 75 with a body-mass index (BMI) of at least 28 or 24 to less than 28 plus at least one weight-related coexisting condition to receive 4 mg of mazdutide, 6 mg of mazdutide, or placebo for 48 weeks in China.
According to a treatment-policy estimand analysis, which evaluated effects independent of early mazdutide or placebo discontinuation and the start of new anti-obesity therapies, the two main endpoints were the percentage change in body weight from baseline and a weight loss of at least 5% at week 32.
At baseline, the mean BMI was 31.1 and the mean body weight was 87.2 kg among 610 individuals. The 4-mg mazdutide group experienced a mean percentage change in body weight from baseline of –10.09% (95% CI), −11.15 to −9.04; the 6-mg mazdutide group experienced a mean percentage change of –12.55% (95% CI, −13.64 to −11.45); and the placebo group experienced a mean percentage change of 0.45% (95% CI, −0.61 to 1.52); 73.9%, 82.0%, and 10.5% of the participants, respectively, experienced a decrease in weight of at least 5%.
The 4-mg mazdutide group experienced a mean percentage change in body weight from baseline of -11.00% (95% CI, −12.27 to −9.73), the 6-mg mazdutide group experienced a mean percentage change of -14.01% (95% CI, −15.36 to −12.66), and the placebo group experienced a mean percentage change of 0.30% (95% CI, −0.98 to 1.58).
Of the participants, 35.7%, 49.5%, and 2.0%, respectively, experienced a weight reduction of at least 15%. Mazdutide showed positive results on all predetermined cardiometabolic measurements. Gastrointestinal side effects were the most commonly reported and were primarily mild to moderate in intensity.
The 4-mg mazdutide dose had a 1.5% incidence of adverse events that resulted in the trial regimen being discontinued, the 6-mg mazdutide dose had a 0.5% incidence, and the placebo had a 1.0% incidence. Overall, treatment with mazdutide at dosages of 4 mg and 6 mg resulted in clinically significant weight reductions at 32 weeks in this research, which included Chinese people who were obese or overweight.
Source:
Ji, L., Jiang, H., Bi, Y., Li, H., Tian, J., Liu, D., Zhao, Y., Qiu, W., Huang, C., Chen, L., Zhong, S., Han, J., Zhang, Y., Lian, Q., Yang, P., Lv, L., Gu, J., Liu, Z., Deng, H., … GLORY-1 Investigators. (2025). Once-weekly mazdutide in Chinese adults with obesity or overweight. The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2411528
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Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751