Study finds daytime meals may reduce health risks linked to night shift work
Researchers at National Institutes of Health have found in a small clinical trial that eating during the nighttime by night shift workers can increase glucose levels, while eating only during the daytime might prevent the higher glucose levels now linked with a nocturnal work life. The findings, the study authors said, could lead to novel behavioral interventions aimed at improving the health...
Researchers at National Institutes of Health have found in a small clinical trial that eating during the nighttime by night shift workers can increase glucose levels, while eating only during the daytime might prevent the higher glucose levels now linked with a nocturnal work life.
The findings, the study authors said, could lead to novel behavioral interventions aimed at improving the health of shift workers - grocery stockers, hotel workers, truck drivers, first responders, and others - who past studies show may be at an increased risk for diabetes, heart disease, and obesity.
The new study, which the researchers noted is the first to demonstrate the beneficial effect of this type of meal timing intervention in humans, appears online in the journal Science Advances. It was funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.
The researchers then evaluated the effects of these meal schedules on their internal circadian rhythms. That's the internal process that regulates not just the sleep-wake cycle, but also the 24-hour cycle of virtually all aspects of your bodily functions, including metabolism.
The researchers found that nighttime eating boosted glucose levels – a risk factor for diabetes – while restricting meals to the daytime prevented this effect. Specifically, average glucose levels for those who ate at night increased by 6.4% during the simulated night work, while those who ate during the daytime showed no significant increases.
"This is the first study in humans to demonstrate the use of meal timing as a countermeasure against the combined negative effects of impaired glucose tolerance and disrupted alignment of circadian rhythms resulting from simulated night work," said study leader Frank A.J.L. Scheer, Ph.D., professor of medicine at Harvard Medical School and director of the Medical Chronobiology Program at Brigham & Women's Hospital in Boston.
The researchers said that the mechanisms behind the observed effects are complex. They believe that the nighttime eating effects on glucose levels during simulated night work are caused by circadian misalignment. That corresponds to the mistiming between the central circadian "clock" (located in the brain's hypothalamus) and behavioral sleep/wake, light/dark, and fasting/eating cycles, which can influence peripheral "clocks" throughout the body. The current study shows that, in particular, mistiming of the central circadian clock with the fasting/eating cycles plays a key role in boosting glucose levels. The work further suggests the beneficial effects of daytime eating on glucose levels during simulated night work may be driven by better alignment between these central and peripheral "clocks."
"This study reinforces the notion that when you eat matters for determining health outcomes such as blood sugar levels, which are relevant for night workers as they typically eat at night while on shift," said the study co-leader Sarah L. Chellappa, M.D., Ph.D., a researcher in the nuclear medicine department at the University of Cologne, Germany. Chellappa formerly worked with Scheer in Brigham & Women's Medical Chronobiology Program.
To translate these findings into practical and effective meal timing interventions, the researchers said more study is needed, including with real-life shift workers in their typical work environment.
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