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  • Two doses of...

Two doses of recombinant zoster vaccine provides strong protection over 4 years even in immunocompromised patients

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-01-11T19:30:52+05:30  |  Updated On 5 Nov 2024 11:05 AM IST
Two doses of recombinant zoster vaccine provides strong protection over 4 years even in immunocompromised patients
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Recent research evaluating the long-term effectiveness of the recombinant zoster vaccine (RZV) against herpes zoster, commonly known as shingles, has shed light on its protective benefits over several years. The study, conducted by Ousseny Zerbo, PhD, and colleagues at Kaiser Permanente Northern California Division of Research, highlights the vaccine's sustained efficacy, especially in individuals receiving two doses.

  • Vaccine Effectiveness: The study involved nearly 2 million participants aged 50 years and older, contributing over 7.6 million person-years of follow-up. After adjustment for various factors, researchers found the overall vaccine effectiveness was 64% for one dose and 76% for two doses of RZV.

  • Long-Term Protection: Individuals receiving two doses exhibited notable effectiveness, with a 73% protection rate against shingles after 3 to 4 years. In contrast, those with partial vaccination showed a lower efficacy of 52% after 4 years.

  • Dose-Specific Effectiveness: The effectiveness of a single dose of RZV declined over time, ranging from 70% in the first year to 52% in the fourth year. Conversely, two fully administered doses maintained stronger protection, with rates around 73% across the third and fourth years.

The findings underscore the importance of complete vaccination, particularly the need for a second dose to enhance and sustain long-term protection against shingles. The research provides crucial real-world evidence supporting the current CDC recommendation of two doses of RZV for individuals aged 50 years and older, emphasizing its role in preventing shingles, especially among higher-risk populations.

The study acknowledges certain limitations, primarily its focus on individuals with health insurance, potentially limiting the broader representation of other demographics. Additionally, the observed effectiveness in this study was slightly lower than previous clinical trials, possibly due to less specific case confirmation methods used in this real-world setting.

Dr. Zerbo and colleagues concluded that the declining effectiveness of a single dose after the first year reinforces the necessity of the second dose. The study advocates for continued vaccination efforts, highlighting the sustained benefits of a two-dose regimen in reducing the risk of shingles among older adults.

Reference:

Herpes zoster shingrix vaccine recommendations. (2023, May 23).


Zoster VaccineRecombinant Zoster VaccineShinglesHerpes ZosterVaccine EffectivenessLong-Term ProtectionClinical TrialsImmunizationCDC Recommendations
Source : Centers for Disease Control and Prevention
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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