TyG index closely associated with progression of depression

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-01-17T20:00:57+05:30 | Updated On 17 Jan 2023 8:01 PM IST

A recent study published in the Journal of Nutrition, Metabolism, and Cardiovascular Diseases found that baseline triglyceride glucose (TyG) index is closely associated with progression of depression. Also, from a metabolic perspective, TyG index monitoring requires more attention for mental health managements.

Cerebral symptoms are common among individuals with non-communicable conditions, while the longitudinal association between triglyceride glucose (TyG) index, indicator of metabolic health, and progression of depression remains unclear. So, this study by Lan Zheng and team aimed to check the association of birth TyG indicator and depression progression in middle-aged and elder grown-ups.

This retrospective cohort study from the National China Health and Retirement Longitudinal Study in visit 1 (2011–2012), they were biennially followed for depression score until visit 4 (2017–2018). The study included 8287 participants over 45 years and 3806 (45.9%) were men.

Multivariate-adjusted regression models were used to evaluate baseline TyG index and its association with the individual level change rate and slope of depression score.

There was no significant difference of depression score at baseline across TyG quartile groups. Compared to those in the lowest, participants in the highest quartile of TyG index had a 0.124 higher change rate of depression score, and a 0.127 higher change slope.

The associations observed were consistent throughout regardless of multiple sensitivity analyses, and stable in men, the elder, and people suffering overweight.

The findings of this study strongly suggest that TyG index is positively associated with progression of depression specially in men, the elders and in obese people, this new insights might help in the primary prevention of depression.

Reference:

Zheng, L., Cui, C., Yue, S., Yan, H., Zhang, T., Ding, M., Sun, Q., He, C., & Ren, H. (2022). Longitudinal association between triglyceride glucose index and depression progression in middle-aged and elder adults: A national retrospective cohort study. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD. https://doi.org/10.1016/j.numecd.2022.11.015

Nutrition Metabolism and Cardiovascular Diseasesmental healthdepressionTriglyceride glucose index

Source : Nutrition, Metabolism, and Cardiovascular Diseases

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751